FOXP1


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FOXP1

(1) A transcription-factor protein encoded by FOXP1 on chromosome 3p14.1, which belongs to subfamily P of the fork-head box transcription-factor family. It has DNA- and protein-binding domains, and plays an important role in cell transformation, differentiation and proliferation.

Normal expression
FOXP1 is widely expressed in normal tissues, and has a predominantly nuclear location in proliferative endometrium and weak cytoplasmic staining in secretory endometerium.

Abnormal expression
Loss of nuclear FOXP1 expression or mislocation in cytoplasm is typical of malignancy—e.g., invasive endometrial carcinoma.

(2) A gene on chromosome 3p14.1 which encodes a winged-helix transcription-factor (FOXP1) in the fork-head box family, which has a key role in cell transformation, differentiation and proliferation.
 
Abnormal expression
FOXP1 overexpression is associated with a lower disease-free survival in diffuse, large B-cell lymphoma.
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References in periodicals archive ?
(2) Thus far, 10 genome-wide association studies on TB have been published; they have identified more than 20 genes associated with the disease including ASAP1, AGMO, FOXP1, which are involved in the functioning of macrophages and dendritic cells.
PARKVILLE, VIC, Australia, October 25, 2018 -- Scientists here have discovered how the growth of milk-producing mammary glands is triggered during puberty, as dormant stem cells in the mammary gland are awakened by a protein dubbed FoxP1.
(21) Unlike PCDLBCL-LT, most cases do not express MUM1, FOXP1, p63, or immunoglobulin M (IgM).
miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1. Blood 2014; 124: 84-95, doi: 10.1182/blood-2013-09-527234.
TFs like Oct4, Nanog and FOXP1 have been linked to various pluripotency or stem cell properties.
Cellular senescence results in the decline of FOXP1 [84] and an increase in miR-188 [88], which correlate with reduced osteogenic differentiation and increased adipogenic differentiation.
Baltimore, "MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1," Immunity, vol.
Borde et al., "Foxp1 is an essential transcriptional regulator of B cell development," Nature Immunology, vol.
It has been described that 3T3-L1-differentiated adipocytes express very low levels when compared with proliferating 3T3-L1 cells [55]; additionally, another two genes related with adipocyte differentiation process, denominated Aamdc [56] and Foxp1 [57], were also downregulated.
FOXP1,2,3,4 proteins are is necessary for the proper development of the brain and lung in mammals FOXP4 may play a role in the development of tumors of the kidney and larynx.