FOXP1


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FOXP1

(1) A transcription-factor protein encoded by FOXP1 on chromosome 3p14.1, which belongs to subfamily P of the fork-head box transcription-factor family. It has DNA- and protein-binding domains, and plays an important role in cell transformation, differentiation and proliferation.

Normal expression
FOXP1 is widely expressed in normal tissues, and has a predominantly nuclear location in proliferative endometrium and weak cytoplasmic staining in secretory endometerium.

Abnormal expression
Loss of nuclear FOXP1 expression or mislocation in cytoplasm is typical of malignancy—e.g., invasive endometrial carcinoma.

(2) A gene on chromosome 3p14.1 which encodes a winged-helix transcription-factor (FOXP1) in the fork-head box family, which has a key role in cell transformation, differentiation and proliferation.
 
Abnormal expression
FOXP1 overexpression is associated with a lower disease-free survival in diffuse, large B-cell lymphoma.
References in periodicals archive ?
By adding GCET1 and FOXP1, Choi et al (66) increased the concordance of immunohistochemical classification of GC versus non-GC to 93%, as compared with gene expression profiling.
Posteriormente se desarrollaron algoritmos con algunas modificaciones como el algoritmo de CHOI, en el que se incluye la expresion de FOXP1 [Forkhead boxprotein 1: es un factor de transcripcion alas helice que actua como un represor transcripcional que se expresa tanto en tejido normal como tejido neoplasico y se expresa en celulas linfoides B pero no en celulas plasmaticas (10, 12)] y GCET1 [Germinal center B-cell expressed transcript-1 gene codifica para una proteina expresada en las celulas B centrogerminales (12)], que se correlacionado con el perfil de expresion genica en algunos estudios hasta en un 87% de los casos.
FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that has been demonstrated to be expressed in a subset of activated B-cell type (ABC) diffuse B-cell lymphomas (DLBCLs).
FOXP1,2,3,4 proteins are is necessary for the proper development of the brain and lung in mammals FOXP4 may play a role in the development of tumors of the kidney and larynx.
That piece is FOXP1, a member of a large gene family that helps regulate tissues throughout the body, including in the heart, lungs and brain.
Bcl-2 but not FOXP1, is an adverse rise factor in immunochemotherapy-treated non-germinal center diffuse large B-cell lymphomas.
The researchers found that in genetic messages of a gene called FOXP1, the switch was active in embryonic stem cells but silent in "adult" cells that had become the specialized cells that comprise organs and perform functions.
They also reported that another gene located in this region, FOXP1, presents loss of expression in 51% of cancers analyzed; however, they did not report LOH in LC samples.
Bcl-2 but not FOXP1, is an adverse risk factor in immunochemotherapy-treated non-germinal center diffuse large B-cell lymphomas.
When comparing the human brain to the non-human primates, the researchers saw more connections among gene networks that featured FOXP1 and FOXP2.
Other systems use combinations of other markers ([Choi et al (45): GCET1, MUM1, CD10, BCL6, FOXP1], [Muris et al (48): BCL2, CD10, MUM1], [Natkunam et al (49): LMO2], [Nyman et al (50): MUM1, FOXP1], and [Meyer et al (51): CD10, GCET1, MUM1, FOXP1, LMO2]) to achieve a more accurate prediction of the gene expression profile results (Figure 3, a through n).