Deacetylation of FOXO3
by Sirt1 or SIRT2 leads to Skp2-mediated FOX03 ubiquitination and degradation.
coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.
protein, Longevity, Allele frequency, Genetics, Aging
gene expression and oxidative status in beta-thalassemia minor subjects.
A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3
and mammalian target of rapamycin.
Cyanidin increased SIRT6 enzyme levels in human colorectal cancer cells, and it was also discovered to decrease the expression of the Twist1 and GLUT1 cancer genes, while increasing the expression of the tumour suppressor FoXO3
gene in cells.
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3
action and atrophy-specific gene transcription.
Additionally, mTOR enhances the NF-[kappa]B signaling pathway by downregulating expression of FOXO3
, suggesting an ability to inhibit autophagy .
Banko et al., "The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3
transcription factor," Journal of Biological Chemistry, vol.
Several Fox members (FoxJ1, FoxM1, FoxO1, and FoxO3
) modulate neurogenesis in adults .
Handschin et al., "PGC-1[alpha] protects skeletal muscle from atrophy by suppressing FoxO3
action and atrophy-specific gene transcription," Proceedings of the National Academy of Sciences of the United States of America, vol.