FOXO3

A gene on chromosome 6q21, which encodes a member of the forkhead family of transcription factors, which is thought to act as a trigger for apoptosis.

Molecular pathology
A translocation of FOXO9 with MLL is associated with secondary acute leukaemia.

References in periodicals archive ?

FOXO3 also was up-regulated (adjusted p value <.

Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an Exploratory Study

This is achieved by the E3-ubiquitin ligases regulating transcription of the Forkhead Box (FOXO) proteins, including the FOXO3 isoform (Okamoto et al.

No effect of a whey growth factor extract during resistance training on strength, body composition, or hypertrophic gene expression in resistance-trained young men

OTCQB: CDXI) and the University of Hawaii said that Cardax's proprietary astaxanthin compound, CDX-085, demonstrated an almost 90% increase in FOXO3 gene expression in mice.

Cardax Touts Study Data Showing that Astaxanthin Compound Stimulates Anti-Aging Gene in Mice

According to a recent study published in the scientific journal Plos One, diminutive males carry the so-called 'longevity gene,' FOXO3, which has been proven to extend the life span of animal test subjects.

Short men tend to live longer due to 'longevity gene'-study

Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53.

Effects of low-dose bisphenol A on DNA damage and proliferation of breast cells: the role of c-Myc

5, 1, 6, and 24 h induced FOXO3 degradation in HT29 cells.

Expression of Transcription Factor FOXO3a is Decreased in Patients with Ulcerative Colitis

They are more likely to carry the FOXO3 gene, that has been proven to increase lifespan in animal tests and is now linked to human height.

The long and the short of it; What height, or lack of it, means for you

Image: An illustration showing how part of the FOXO3 protein connects with DNA.

7 secrets about the science of aging you ought to know

Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/ Akt signaling to improve the effects of exercise in elderly rat hearts.

Major advance in slowing aging

Willcox noted that there is no specific height or age range that should be targeted as a cut-off in the study, in part because "no matter how tall you are, you can still live a healthy lifestyle" to offset having a typical FOXO3 genotype rather than the longevity-enhancing form of the FOXO3 gene.

Study: Shorter Men Live Longer

The researchers showed that shorter men were more likely to have a protective form of the longevity gene, FOXO3, leading to smaller body size during early development and a longer lifespan.

Shorter men live longer: Study

SIRT1 also deacetylates the transcription factors FOXO3 and/or FOXO4, which leads to attenuation of FOXO-induced apoptosis and cell- cycle arrest (Giannakou and Partridge, 2004).

SIRT1: Importance of O-GlcNAc and Phosphorylation Interplay in Aging and Diabetes