FOXO3

FOXO3

A gene on chromosome 6q21, which encodes a member of the forkhead family of transcription factors, which is thought to act as a trigger for apoptosis.
   
Molecular pathology
A translocation of FOXO9 with MLL is associated with secondary acute leukaemia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Deacetylation of FOXO3 by Sirt1 or SIRT2 leads to Skp2-mediated FOX03 ubiquitination and degradation.
Keywords: FOXO3 protein, Longevity, Allele frequency, Genetics, Aging
Foxo3 gene expression and oxidative status in beta-thalassemia minor subjects.
A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin.
Cyanidin increased SIRT6 enzyme levels in human colorectal cancer cells, and it was also discovered to decrease the expression of the Twist1 and GLUT1 cancer genes, while increasing the expression of the tumour suppressor FoXO3 gene in cells.
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
Additionally, mTOR enhances the NF-[kappa]B signaling pathway by downregulating expression of FOXO3, suggesting an ability to inhibit autophagy [75].
Banko et al., "The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor," Journal of Biological Chemistry, vol.
Handschin et al., "PGC-1[alpha] protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription," Proceedings of the National Academy of Sciences of the United States of America, vol.