FOXO1

FOXO1

The gene on chromosome 13q14.1 which encodes a forkhead family transcription factor that regulates cell responses to oxidative stress. In the presence of KIRT1, it downregulates cyclin D1 and upregulates CDKN1B as required for cell transition from proliferation to quiescence. It may play a role in myogenic growth and differentiation.

Molecular pathology
FOXO1 translocation with PAX3 has been associated with alveolar rhabdomyosarcoma.
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Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FOXO1 -sestrin3-AMPK signaling cascade in myocytes.
It has been demonstrated that FSH stimulation of rat GCs led to PI3Kinase/ AKT activity which by phosphorylation of FOXO1 relieves repression of Lhcgr promoter activity (28).
2+] homeostasis, and myocardial fibrosis resulting in heart disease have been recently reported, as well as increased nuclear and acetylated levels of FOXO1 with corresponding inverse changes in SIRT1 levels in the heart which are corrected by resveratrol therapy.
Children with fusion-negative tumours lack a particular genetic defect often found in rhabdomyosarcoma that results in two genes, called PAX3 and FOXO1, becoming fused together.
The Columbia researchers were able to teach human gut cells to make insulin in response to physiological circumstances by deactivating the cells' FOXO1 gene.
The scientists were able to teach human gut cells to make insulin in response to physiological circumstances by deactivating the cells' FOXO1 gene.
Functional regulation of DNA binding of FOXO1 by post translational modifications: In silico study.
Furthermore the inhibition of miR-182 showed anti-inflammatory properties over the target gene FOXO1.
36) Activation of the acquired immune response elevated osteoclastogenesis and decreased bone formation associated with an increase in nuclear translocation of the transcription factor FOXO1 (forkhead box O1) in vivo, enhanced apoptosis of bone lining cells caspase-3 positive cells and a decrease in bone lining cell density.
Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control.
1] Nonstandard abbreviations: hepcidinl, mouse hepcidin antimicrobial peptide 1; PGC-1[alpha], peroxisome proliferator-activated receptor [gamma] coactivator 1[alpha]; HNF4[alpha], hepatocyte nuclear factor 4[alpha]; FOXO1, forkhead box O1 protein.
Through experiments in human cells, human lung cancer tissue and mouse lung tissue, the team found that trifluoperazine was able to stop the product of a gene called FOXO1 from being taken out of a tumor cell's nucleus.