FOXN1

FOXN1

A gene on chromosome 17q11-q12 that encodes a member of the forkhead family of transcription factors, which is thought to regulate keratinisation.

Molecular pathology
FOXN1 mutations are linked to T-cell immunodeficiency and thymic carcinoma, congenital alopecia, and nail dystrophy.
References in periodicals archive ?
Congenital athymia is a rare and deadly condition associated with complete DiGeorge Anomaly, CHARGE syndrome, and FOXN1 deficiency.
It has recently been shown that induced expression of the forkhead transcription factor FOXN1 in mouse embryonic fibroblasts (MEFs) can convert these cells into thymic epithelial cells (TEC) referred to from here out as induced Thymic Epithelial Cells (iTEC).
Detection of the gene expression of FoxN1, FoxE1, and FoxI3 in skin hair follicles of Inner Mongolia cashmere goats: Realtime quantitative polymerase chain reaction (qPCR) detecting system was used to quantify the expression levels of the genes FoxN1, FoxE1, and FoxI3 and mRNA in skin samples from cashmere goat collected at different fetal and adult stages.
Although thymocytes possess their own transcription factors (TFs) to control their autonomous activities, many thymic activities during thymic development and aging can be regulated by known TFs in TECs, such as the p63 and FoxN1 [10-13].
That gene technique involves a "transcription factor" with the unusual name of "forkhead box N1," or Foxn1. Declining natural levels of Foxn1 have been implicated as a major cause of loss of thymus tissue with aging.
The researchers targeted a protein produced by cells of the thymus -- called FOXN1 -- which helps to control how important genes are switched on.
A gene, called Foxn1, naturally shuts down as the thymus ages and the team tried to bring it back to youthful levels.
Gawronska-Kozak, "Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression," Matrix Biology, vol.
To validate microarray data, we analysed SFN, FOXN1, Krt15, LHX2, CD34, and SOX9 gene expression by using mouse-predesigned oligos (Assay IDs: Mm.PT.58.42262048.g, Mm.PT.58.13135783, Mm.PT.58.5528981, Mm.PT.58.6480133, Mm.PT.58.8626728, and Mm.PT.58.42739087, resp., IDT[R]) and K6b-designed oligos (5'-CATCAAATACACCACCAGCG-3' (forward) and 5'-AAGCAGCCAAAAAGAGAAGC-3' (reverse)).
Evolutionarily constrained inventories of such genetic networks will be additionally used for the design of synthetic thymopoietic environments in non-cognate tissues, either using combinations of thymopoietic factors or by exploiting the thymopoietic capacity of Foxn1, a master regulator of thymic epithelial cell differentiation.
The genotypes of each sample are represented by blue diamonds (homozygous Foxn1rnu), red circles (homozygous for the wild-type Foxn1 allele), or green triangles (heterozygous +/Foxn1rnu).