FOXN1

A gene on chromosome 17q11-q12 that encodes a member of the forkhead family of transcription factors, which is thought to regulate keratinisation.

Molecular pathology
FOXN1 mutations are linked to T-cell immunodeficiency and thymic carcinoma, congenital alopecia, and nail dystrophy.

References in periodicals archive ?

Congenital athymia is a rare and deadly condition associated with complete DiGeorge Anomaly, CHARGE syndrome, and FOXN1 deficiency.

US FDA Accepts Enzyvant Biologics License Application and Priority Review Status for RVT-802, a Novel Investigational Tissue-Based Regenerative Therapy for Pediatric Congenital Athymia

It has recently been shown that induced expression of the forkhead transcription factor FOXN1 in mouse embryonic fibroblasts (MEFs) can convert these cells into thymic epithelial cells (TEC) referred to from here out as induced Thymic Epithelial Cells (iTEC).

INDUCED THYMIC EPITHELIAL CELLS(ITEC) AS A TOOL FOR REPAIRING ADAPTIVE IMMUNITY IN PATIENTS

Detection of the gene expression of FoxN1, FoxE1, and FoxI3 in skin hair follicles of Inner Mongolia cashmere goats: Realtime quantitative polymerase chain reaction (qPCR) detecting system was used to quantify the expression levels of the genes FoxN1, FoxE1, and FoxI3 and mRNA in skin samples from cashmere goat collected at different fetal and adult stages.

Expression of fox-related genes in the skin follicles of Inner Mongolia cashmere goat

Although thymocytes possess their own transcription factors (TFs) to control their autonomous activities, many thymic activities during thymic development and aging can be regulated by known TFs in TECs, such as the p63 and FoxN1 [10-13].

MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors

Effect of boric acid supplementation of ostrich water on the expression of Foxn1 in thymus.

Effects of Supplemental Boron on Intestinal Proliferation and Apoptosis in African Ostrich Chicks/Efectos del Boro Suplementario sobre la Proliferacion Intestinal y Apoptosis en Polluelos de Avestruz Africana

That gene technique involves a "transcription factor" with the unusual name of "forkhead box N1," or Foxn1. Declining natural levels of Foxn1 have been implicated as a major cause of loss of thymus tissue with aging.

Scientists create world's first fully functioning organ

The researchers targeted a protein produced by cells of the thymus -- called FOXN1 -- which helps to control how important genes are switched on.

Living Organ Regenerated for First Time

A gene, called Foxn1, naturally shuts down as the thymus ages and the team tried to bring it back to youthful levels.

Gene manipulation helps regenerate organs for first time ever

Gawronska-Kozak, "Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression," Matrix Biology, vol.

Regulating inflammation using acid-responsive electrospun fibrous scaffolds for skin scarless healing

To validate microarray data, we analysed SFN, FOXN1, Krt15, LHX2, CD34, and SOX9 gene expression by using mouse-predesigned oligos (Assay IDs: Mm.PT.58.42262048.g, Mm.PT.58.13135783, Mm.PT.58.5528981, Mm.PT.58.6480133, Mm.PT.58.8626728, and Mm.PT.58.42739087, resp., IDT[R]) and K6b-designed oligos (5'-CATCAAATACACCACCAGCG-3' (forward) and 5'-AAGCAGCCAAAAAGAGAAGC-3' (reverse)).

The PDZ-Binding Motif of HPV16-E6 Oncoprotein Modulates the Keratinization and Sternness Transcriptional Profile In Vivo

Evolutionarily constrained inventories of such genetic networks will be additionally used for the design of synthetic thymopoietic environments in non-cognate tissues, either using combinations of thymopoietic factors or by exploiting the thymopoietic capacity of Foxn1, a master regulator of thymic epithelial cell differentiation.

Thymopoiesis: From Evolutionary Origins to Future Therapies

The genotypes of each sample are represented by blue diamonds (homozygous Foxn1rnu), red circles (homozygous for the wild-type Foxn1 allele), or green triangles (heterozygous +/Foxn1rnu).

Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models