FOXL1

FOXL1

A gene on chromosome 16q24 that encodes a member of the forkhead family of transcription factors.
References in periodicals archive ?
In Drosophila melanogaster, loss of FoxL1 affects the salivary gland position and morphology during embryonic development [16].
Andrew, "Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development," Developmental Biology, vol.
(2009) FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.
FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1. Clin Cancer Res.
(12) Recientemente, se han identificado microdelecciones del grupo de genes FOX en 16q24.1, que consta de cuatro genes, FOXF1, MTHFSD FOXC2, y FOXL1, como causantes de un fenotipo parecido a la asociacion VACTERL, con anomalias vertebrales, atresias gastrointestinal (esofago, duodeno o ano), cardiopatias congenitas y malformaciones del tracto urinario, asi como una rara anomalia letal de desarrollo del pulmon, la displasia capilar alveolar.
The researchers found that these dual-potential stem cells can be identified and potentially isolated from other liver cells because they uniquely express the protein Foxl1.
The team showed that in two mice models of liver injury, stem cells and their descendents were marked by the expression of FoxL1.
Similarly, another recent study shows that the CD34+ gp38+ pericryptal mesenchymal cells (also express Foxl1) are the major intestinal source for the ISC niche factors such as Wnt2b, R-spondin, and Gremlin1 [88].
On this direction, recent studies show that a subpopulation of mesenchymal cells marked by the winged-helix transcription factor Foxl1 is critical in maintaining stem cells.