The lack of FoxI3 prevents the downward growth of the hair follicles and obstructs the hair cycle .
Detection of the gene expression of FoxN1, FoxE1, and FoxI3 in skin hair follicles of Inner Mongolia cashmere goats: Realtime quantitative polymerase chain reaction (qPCR) detecting system was used to quantify the expression levels of the genes FoxN1, FoxE1, and FoxI3 and mRNA in skin samples from cashmere goat collected at different fetal and adult stages.
The expression levels of FoxN1, FoxE1, and FoxI3 genes in samples of skin tissues collected at different time points of the fetal and adulthood periods of cashmere goats.
Because genes FoxN1, FoxE1, and FoxI3 are not goat-derived antibodies, we chose a highly homologous primary antibody derived from rabbit or murine.
Basing on the evidence of some recent reports of studies on hair follicle development at home and abroad, we hypothesized that these three genes of the Fox gene family (FoxI3, FoxN1, and FoxE1) are probably involved in the growth and development of the follicle and the formation of the hair.
Expression of genes FoxN1, FoxE1, and FoxI3 in skin tissue of Inner Mongolia cashmere goat
Relative expression level of FoxN1, FoxE1, and FoxI3 genes in cashmere goat fetal skin hair follicles: The genes FoxN1, FoxE1, and FoxI3 were expressed in the skin tissue of cashmere goat fetus in all 10 experimental time points (Figure 5).
Relative expression levels of FoxN1, FoxE1, and Foxl3 genes in skin hair follicles of adult cashmere goats: FoxN1, FoxE1, and FoxI3 genes were expressed in the skin of adult cashmere goats at different stages of their age (Figure 6).
This paper focuses on FoxN1 and FoxI3 was contained in these 204 genes.
Relationship between FoxN1, FoxE1, and FoxI3 genes and the origin and development of the hair follicle
They discovered that a mutation in the hairless dogs had been inherited from a unique ancestral, thus giving the now well-known name of the gene FoxI3. In dogs, FoxI3 haploinsufficiency leads to poor embryo development, which is characterized by an almost entire absence of hairs.