FOXD3

FOXD3

A gene on chromosome 1p3.13 that encodes a member of the forkhead family of transcription factors.

Molecular pathology
FOXD3 mutations increase susceptibility to autoimmune disorders.
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References in periodicals archive ?
FOXD3 suppresses tumor growth and angiogenesis in non-small cell lung cancer.
The depletion of cMYC in Xenopus embryos leads to inhibition of expression or complete absence of early neural crest markers such as slug, twist, and foxd3, as well as to the absence of a different kind of neural crest derivatives characteristic for late stages of embryonic development, namely, mesectodermal neural crest precursors that give rise to the facial skeleton [44].
Previous studies showed that HFH-2 (alias Foxd3) decreased interleukin-10 expression in B cells, and FOXD3/miR-214/MED19 axis sup presses tumors growth and metastasis in human colorectal cancer [20,21].
Otros factores de transcripcion igualmente asociados son Sox, Snail, Slug y FoxD3, que a su vez pueden inducir la represion de E-cadherina y demas genes relacionados con la polaridad celular [4].
Also, dysregulation of FOXD3 promotes gastric carcinogenesis [222].
Negative feedback loops that regulate ESC pluripotency involving Oct4, FoxD3, and Nanog are known [158].
These CRMs have the length of at most 164 bp and contain binding sites of three TFs: Oct4, So[x.sup.2], and FoxD3. The distance between these TFBSs follows a Poisson distribution with expectation of 10.
Downregulation of the transcription factor, FoxD3, is associated with lymph node metastases in invasive ductal carcinomas of the breast.
The study showed that a gene called FOXD3 likely plays a key role in CLL, and that the gene is silenced early, followed by the silencing of other genes.