They identified two transcription factors, Sox9 and Foxc1
, as key to the differentiation of stem cells into salivary gland tissue.
Chen et al., "A novel long non-coding RNA FOXCUT and mRNA FOXC1
pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma," International Journal of Clinical and Experimental Pathology, vol.
However, no such gene has been discovered and known anterior segment developmental control genes such as PAX6 , FOXC1
, and PITX2  are not associated with PDS/PG but are instead causative of other types of glaucoma .
Mechanistically, XIST regulates the expression of the transcription factor Forkhead Box C1 (FOXC1
) and Zonula occludens 2 (ZO-2), two molecules essential for maintaining the BTB integrity, by dampening miR-137 .
Liu et al., "Foxc1
and Foxc2 in the neural crest are required for ocular anterior segment development," Investigative Ophthalmology & Visual Science, vol.
(28) A potential target of loss of heterozygosity in 6q25.2-25.3 is the tumor suppressor gene FOXC1
. (28) In addition, Petrini et al (63) showed that frequent copy number loss of FOXC1
is associated with more aggressive tumors and correlates with decreased protein expression.
Mutations in a variety of genes associated with early-onset glaucoma, including MYOC, CYP1BI, FOXC1
, PITX2, PAX6, and OPTN, typically disrupt normal development of the trabecular outflow pathway .
Kang et al., "Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1
as susceptibility loci for primary open-angle glaucoma," Nature Genetics, vol.
For some transcription factors such as STAT1, AR, HLF, ZEB1, TCF21, ISL1, KLF6, HOXB13, SIM2 and FOXA1, the number of interactions in the metastasis stage decreased dramatically (Table 3); the interaction numbers of other transcription factors, such as ZNF-529, FOXC1
, MNX1, and JUNB, increased considerably in the metastasis stage, indicating network rewiring (Table 3).
[7-10] The genes at chromosomes 4q25 and 6p25 have been identified as PITX2 and FOXC1
.  About 40% of Axenfeld--Rieger sufferers display mutations in one of the genes known as PAX6, PITX2 and FOXC1
(ii) Peters syndrome caused by mutations involving PAX6, PITX2, CYP1B1, or FOXC1
Qu et al., "FOXC1
is a potential prognostic biomarker with functional significance in basal-like breast cancer," Cancer Research, vol.