FOXA3

FOXA3

A gene on chromosome 19q13.2-q13.4 that encodes a member of the forkhead class of DNA-binding proteins, hepatocyte nuclear factors, which are transcription activators for liver-specific transcripts—e.g., albumin and transthyretin—and interact with chromatin. Homologues in mice have roles in regulating metabolism and differentiation of the pancreas and liver.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Mizuguchi, "Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction," Scientific Reports, vol.
The scientists were also able to pinpoint the role of the Foxa3 gene, which was shown for the first time to play an important role in repopulating blood-forming stem cells in the experimental system used by the researchers.
Foxa3 likely regulates the blood-cell-forming response that takes place under the conditions of stress experienced after transplantation.
Studies in other tissues have demonstrated the requirement of factors such as Fox[alpha]1, Foxa2, Foxa3, and Spdef for colonic and airway epithelial goblet cell development [59-63].