FOXA2

FOXA2

A gene on chromosome 20p11 that encodes a member of the forkhead class of DNA-binding proteins, hepatocyte nuclear factors, which are transcription activators for liver-specific transcripts—e.g., albumin and transthyretin—and interact with chromatin. Homologues in mice have roles in regulating metabolism and differentiation of the pancreas and liver.
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References in periodicals archive ?
(2015) reported that the metabolic pathways of lipid deposition and elimination are regulated tightly by the nutritionally regulated transcription factors Foxo1, Foxa2, ChREBP and SREBP-1c.
Moreover, propofol was found to decrease LPS-induced production of monocyte chemoattractant protein-1 (a cytokine that mediates cell influx to inflammatory sites) via increasing expression of apoM and forkhead box protein A2 (foxa2) in human liver carcinoma (HepG2) cells [8].
Hwang, "Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos," Biochemical Journal, vol.
Kawabata et al., "Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1a transduction," Journal of Hepatology, vol.
The following markers were used to determine differentiation efficiency: brachyury (R&D Systems) for mesoendoderm, Nkx2.5 (Abcam) for cardiac mesoderm, Nkx2.5 and Isl1 (Developmental Studies Hybridoma Bank) for cardiac progenitors, cTnT (Thermo Fisher Scientific) for cardiomyocytes, double staining of FOXA2 (GeneTex) and SOX17 (GeneTex) for endoderm, CDX2 (GeneTex) for mid/hindgut, Otx2 (R&D Systems) for day 5 neural induction, and PAX6 (GeneTex) for neuroepithelium [17-20].
At day 11, immunofluorescence analysis of F3 midbrain floor plate precursors showed the distinctive coexpression of the floor plate marker FOXA2 and the roof plate marker LMX1-A [37].
l) Mutations in Forkhead Box Protein A2 (FOXA2) and CHI (Single Case Report)
Further study showed Id genes enable heart formation by turning down the Tcf3 and Foxa2 proteins, which inhibit the process, and turning up Evx1, Grrp1 and Mesp1, which support the process.
Moreover, other markers for specific parts of the brain, such as ventral midbrain neuron markers LMX1A, FOXOl and FOXA2 (Hedlund et al., 2016; Stott et al., 2013), cerebral cortex marker FOX04, markers for myelination CNP and MBP (Li and Richardson, 2008; Agrawal et al., 1994), and a marker for L-glutamate transport SLC1A6 (Sery et al., 2015) were studied (Fig.
This intrinsic hepatic potential of the anterior intestine may be attributed to FOXA2, GATA4-6, and HHEX transcription factors, which play crucial roles in the early organogenesis of this part of the intestinal tract (7, 8).
This SNP was also found to be positioned within a site bound by multiple transcription factors including specificity protein 1 (SP1) and fork head box A2 (FOXA2), also in HepG2 cells.