FOXA2

FOXA2

A gene on chromosome 20p11 that encodes a member of the forkhead class of DNA-binding proteins, hepatocyte nuclear factors, which are transcription activators for liver-specific transcripts—e.g., albumin and transthyretin—and interact with chromatin. Homologues in mice have roles in regulating metabolism and differentiation of the pancreas and liver.
References in periodicals archive ?
Moreover, other markers for specific parts of the brain, such as ventral midbrain neuron markers LMX1A, FOXOl and FOXA2 (Hedlund et al.
As a matter of fact, it has been shown that FOXA1 and FOXA2 deletion inhibit the liver growth from the anterior intestine in the early period (9).
On the postcoital 35-37th day, the pancreas moves away from the aorta, and PDX1, FOXA2, SOX9, and NKX6.
2], XIAP, BAX, CASP3, CASP8, CASP9, FOXA2, HNF4A, EBP, HGF, NFKB2, STAT3, IL6, I[L.
DE markers FOXA2, SOX17 and CXCR4 and also pluripotency marker OCT4 were evaluated using qRT-PCR, as well as FOXA2 by the immunocytochemistry.
Similarly, the immunocytochemistry analysis demonstrated that the differentiated hiPSCs expressed FOXA2, with no significant differences.
Also, DE marker FOXA2 expression was evaluated at the protein level using immunocytochemical analysis.
33% of the generated cells using five methods expressed FOXA2 (Figure 3).
The "transcription factors" FOXA2 and HNF1A activate a pancreatic enzyme that in healthy people prevents diabetes developing.
Experiments in mice showed that preserving the function of the enzyme affected by FOXA2 and HNF1A blocked the onset of diabetes, even in obese animals.