FOXA1

FOXA1

A gene on chromosome 14q12-q13 that encodes a member of the forkhead class of DNA-binding proteins, hepatocyte nuclear factors, which are transcription activators for liver-specific transcripts—e.g., albumin and transthyretin—and interact with chromatin. Homologues in mice have roles in regulating metabolism and differentiation of the pancreas and liver.
References in periodicals archive ?
The team discovered the changes affecting the activity of two well known drivers of breast cancer - the estrogen receptor ESR1 and the transcription factor FOXA1 - that work together in breast cancer cells.
FOXA1 biomarker predicts likelihood of recurrence and long-term disease-free survival of breast cancer patients; Further strengthens Company's breast cancer menu
Clarient's agreement to license FOXA1 from IURTC provides for another strong marker to help identify these luminal A subtypes.
The FOXA1 marker, also known as forkhead box A1, is a gene known to cause breast cancer.
Clarient CEO Ron Andrews noted that FOXA1 has shown it can predict risk of cancer recurrence in ER-positive, node-negative breast cancer patients.
In addition to SPOP mutations, which occurred in 6 to 15 percent of tumours across multiple independent cohorts, investigators found mutations in the FOXA1 and MED12 genes, each of which are found in about 4 percent of patient tumors.
Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression.