FOXA1

FOXA1

A gene on chromosome 14q12-q13 that encodes a member of the forkhead class of DNA-binding proteins, hepatocyte nuclear factors, which are transcription activators for liver-specific transcripts—e.g., albumin and transthyretin—and interact with chromatin. Homologues in mice have roles in regulating metabolism and differentiation of the pancreas and liver.
References in periodicals archive ?
GATA-3 and FOXA1 expression is useful to differentiate breast carcinoma from other carcinomas.
As a matter of fact, it has been shown that FOXA1 and FOXA2 deletion inhibit the liver growth from the anterior intestine in the early period (9).
306212 CAV1, EIF4EBP1, TNF, FOXA1, HR, LMCD1, CBY1 GOTERM_BP_FAT 7 0.
For some transcription factors such as STAT1, AR, HLF, ZEB1, TCF21, ISL1, KLF6, HOXB13, SIM2 and FOXA1, the number of interactions in the metastasis stage decreased dramatically (Table 3); the interaction numbers of other transcription factors, such as ZNF-529, FOXC1, MNX1, and JUNB, increased considerably in the metastasis stage, indicating network rewiring (Table 3).
Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression.
The team discovered the changes affecting the activity of two well known drivers of breast cancer - the estrogen receptor ESR1 and the transcription factor FOXA1 - that work together in breast cancer cells.
In addition to SPOP mutations, which occurred in 6 to 15 percent of tumours across multiple independent cohorts, investigators found mutations in the FOXA1 and MED12 genes, each of which are found in about 4 percent of patient tumors.
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.
Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours.