FOSL2

FOSL2

A gene on chromosome 2p23.3 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis. FOSL2 controls osteoclast survival and size; it forms a heterodimer with JUN, activates LIF transcription and activates CEBPB transcription in PGE2-activated osteoblasts.
References in periodicals archive ?
In addition to STAT3 and [ROR[gamma], many other transcript factors play a critical role in Th17 differentiation, including basic leucine zipper ATF-like transcript factor (BATF), IRF4, fos-related antigen 2 (FOSL2), and [ROR[gamma] [25-29].
FOSB, another member in FOS gene family, had 2.56 fold changes while other two members, FOSL1 and FOSL2 did not change significantly (1.06 and 1.12 fold change, respectively) [20].
Bozec et al., "FOSL2 promotes leptin gene expression in human and mouse adipocytes," The Journal of Clinical Investigation, vol.
Hu et al., "The expression level of mRNA, protein, and DNA methylation status of FOSL2 of Uyghur in Xinjiang in type 2 diabetes," Journal of Diabetes Research, vol.
Other DEGs involved in vascular damage and targeted by modulated miRNAs were FOSL2, THBD, and PTX3.