FOSB


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FOSB

A gene on chromosome 19q13.32 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.
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SERPINE1 is believed to be a promoter for FOSB; this translocation is not found in any other soft tissue tumors and is considered pathognomonic for PH.
Differential peak calling on NMDA-treated samples showed that yH2AX enrichment was confined to only 21 loci including the nIEGs Fos, FosB, Npas4, Egr1, Nr4a1, and Nr4a3 among other transcription factors and noncoding RNAs, pointing to the specific localisation of DSB induction following neuronal stimulation [12].
Zusanli (ST-36) and Sanyinjiao (SP-6) were shown to significantly reduce cue-induced reinstatement of heroin seeking in rats, with attenuation of FosB expression in the NAc core, (69) and other regions including anterior and posterior cingulate cortex, central nucleus of amygdala, NAc shell, VTA, and locus coeruleus.
In details, increased intracellular calcium leads to activation of constitutively expressed NO synthases, and increased NO production in osteoblasts.[sup][61],[62] NO further activates PKG II, which phosphorylates substrates make the MEK/Erk pathway activated.[sup][63],[64],[65] Furthermore, the MEK/Erk pathway increases transcription of c-fos, fra-1, fra-2, and fosB,[sup][66],[67] which is via the following activation of cAMP-response element binding protein (CREB), direct phosphorylation of Elk and recruitment of AP-1 complexes.[sup][68],[69],[70] These fos family genes encode members of the AP-1 transcription factor family that regulate osteoblast proliferation and differentiation.[sup][71]
Knoll Araliaceae Polyscias Saucer-leaf Salapiin leaves, scutellaria roots (Burm.f) Fosb. Arecaceae/Palmae Cocos Golden Lubi nga bark, roots nucifera L.
Breadfruit (Artocarpus altilis Fosb.)--An underutilized and neglected fruit plant species.
A defect in nurturing in mice lacking the immediate early gene fosB. Cell, 86(2), 297-309.
After 30 days of storage, the mechanical properties were evaluated in the films FNS, FOSA, and FOSB, obtaining results of tensile strength (TS) and percentage of elongation (%E) presented in Figure 2.
Gene Drug FACS, Culture astrocytes astrocytes ADAR2 Fluoxetine Up Up [5-HT.sub.2B] receptor expression Fluoxetine Up Up [5-HT.sub.2B] editing Fluoxetine Up Up [5-HT.sub.2C]receptor expression Fluoxetine Unchanged Unchanged [cPLA.sub.2a] Fluoxetine Up Up [sPLA.sub.2] Fluoxetine Unaltered Unaltered GluK2 expression Fluoxetine Up Up GluK2 editing Fluoxetine Up Up GluK4 expression Fluoxetine Unchanged Unchanged cfos expression Fluoxetine Up Up fosB expression Fluoxetine Up Up [Ca.sub.v ]1.2 Fluoxetine Up Up NBCel Carbamazepine Up Up GluK2 Carbamazepine Down Down [cPLA.sub.2] Carbamazepine Up Up Table 1 shows all experiments in which drug effects were compared in cultured astrocytes and in astrocytes freshly obtained by FACS as described by Lovatt et al.
This mechanism has been shown to play a role in cocaine-induced regulation of FosB (Levine et al.