FOLFIRI


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FOLFIRI

Leucovorin, irinotecan, and fluorouracil, chemotherapeutic agents used to treat solid tumors, such as those arising in the colon or pancreas.
References in periodicals archive ?
The Cetuximab Combined With Irinotecan in First-Line Therapy for Metastatic Colorectal Cancer (CRYSTAL) phase III trial enrolled 599 patients to receive FOLFIRI plus cetuximab and 599 patients in the arm with FOLFIRI alone [210].
In situation 4, that is FOLFOX versus FOLFIRI again, but after a first line with LV5FU2, the estimated Kendall's [tau] was slightly higher: 0.225.
Our patient was initially treated with GC (gemcitabine and cisplatin) and subsequently with FOLFIRI, a 5-FU based regimen, resulting in partial tumor shrinkage that enabled curative surgery.
Capecitabine treatment did not reverse the progression; however, 2 cycles of chronomodulated bevacizumab plus FOLFIRI dramatically shrank the tumors again, as shown with CT imaging 16 months after the first SIRT treatment.
Conversion chemotherapy can render initially unresectable liver metastasis to secondary resectability using modern chemotherapy regimens that include folinic acid, fluorouracil, and oxaliplatin (FOLFOX) and folinic acid, fluorouracil, and irinotecan (FOLFIRI).[sup][4],[5],[6] In addition, chemotherapy efficacy can be increased using monoclonal antibodies, such as cetuximab and bevacizumab.[sup][7],[8] Combining chemotherapy with an aggressive repeat surgical resection, radiofrequency ablation (RFA), and transcatheter arterial chemoembolization may yield a potentially curative treatment and a high long-term survival rate for patients with unresectable CLM.[sup][9]
Abstract 2535, AA [gamma]- Inhibit of final RO4929097 + Completed/NCT01131234 Secretase Notch cleavage AZD2171 inhibitor by [gamma]- (GSI)/VEGFR secretase and tyrosine stop the growth kinase of tumor cells inhibitor by blocking some of the enzymes needed for cell growth * Chemotherapy agent: CP (carboplatin plus paclitaxel); EP (etoposide), CDDP (cisplatin), CBDCA (carboplatin); DTX (docetaxel); OSI-774 (Erlotinib); chemoregimens: PTX (paclitaxel), 5-FU plus irinotecan (FOLFIRI), or CP (carboplatin plus paclitaxel).
In the palliative treatment setting, one patient received 4 cycles of FOLFOX regimen as the first-line chemotherapy, one received 4 cycles of FOLFIRI (irinotecan, 5-FU plus leucovorin) regimen as the second-line chemotherapy.
In a randomized controlled trial of cetuximab plus chemotherapy for patients with WT KRAS unresectable colorectal liver-limited metastases, the combination of cetuximab with FOLFIRI (fluorouracil, leucovorin, and irinotecan) or mFOLFOX6 (modified fluorouracil, leucovorin, and oxaliplatin) in one arm and chemotherapy alone in another arm were compared and results showed that patients in the combination arm had improved objective response rates (57.1 vs.
Se prescribe una segunda linea de quimioterapia con FOLFIRI (5-FU mas irinotecan) y bevacizumab.
The chemotherapy regimens that administered, consisted of drugs such as FOLFOX, FOLFIRI, AVASTIN, Xeloda, Oxaliplatin, 5-FU, Mitomicyn C.
In 2012, Sanofi/Regeneron's Zaltrap (ziv-aflibercept) was approved by the FDA in combination with FOLFIRI for the treatment of metastatic CRC that has become resistant or progressed on prior oxaliplatin-containing combination therapy (FDA, press release, August 3, 2012).