Allelic frequency of the largest ([is greater than] 21 repeats) and the smallest ([is less than] 16 repeats) FMR2 alleles was examined among children with above average (n = 50) vs.
The results support the contention that normal variation in FMR2 gene size does not account for variability in intellectual scores.
The presence of these difficulties may have been associated with other factors, genetic or nongenetic, that may potentially interact with any effects of FMR2 size on intelligence in such a way as to diminish the apparent effect of the latter.
An issue related to ascertainment of the participant sample concerns how representative the present sample is of the general population, with respect to FMR2 allele size.
Allelic frequency differences for FMR2 have been reported elsewhere.
If the FMR2 gene size was associated with variation in intelligence, the degree of association would not be expected to be large, nor would it be expected to work in isolation from other genetic and nongenetic factors.
Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island.
Identification of the gene FMR2, associated with FRAXE mental retardation.