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A gene on chromosome 16p13.3 of the RetRo gene family that encodes pyrin or marenostrin, an important modulator of innate immunity, which is thought to control the inflammatory response in myelomonocytic cells at the level of the cytoskeleton.

Molecular pathology
Defects in MEFV cause Familial Mediterranean fever, both the autosomal dominant and autosomal recessive forms.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


1. Familial Mediterranean fever.
2. Fetal movement felt.
3. Forced mid-expratory flow.
4. Free molecular flow.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Patient discussion about FMF

Q. Can Familial Mediterranean Fever (FMF) cause a heart enlargement? A friend of mine is suffering from FMF. its usually doesn't bother him that much and when it dose the symptoms are stomach ache and fever. he has no heart symptoms and takes no medications. his physician told him that because of the FMF he might suffer from a heart enlargement, and that he should take some oral medications daily to prevent it. how can it be?

A. This question can't be answered with a strict yes or no.
although FMF on its own can't cause heart enlargement, FMF can cause amyloidosis because of the recurrent inflammation. this may lead to enlargement of the heart which is a severe disease.
the good side is that taking medication can decrease the chance of the cardiac enlargement.

More discussions about FMF
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References in periodicals archive ?
LMR of the appendicitis group was significantly lower than those in the other groups (p=0.001each), but no significant difference could be found between FMF and ML groups (p=0.149).
In this study, 22 (13 males and nine females) patients with FMF with colchicine resistance or intolerance, age ranging from 6 to 18 years, were included in Ege University Department of Pediatric Rheumatology.
Many skin lesions, such as purpuric rash, ELE, Henoch-Schonlein purpura, and angioneurotic edema can be seen in FMF cases.
The demographic and clinical features of the FMF patients and matched controls are summarized in Table I.
Genetic linkage study of familial Mediterranean fever (FMF) to 16pl3.3 and evidence for genetic heterogeneity in the Turkish population.
But instead of considering the request, LDA has arbitrarily sealed the premises, FMF stated.
In the present study, we aimed to investigate whether children with FMF have nail fold capillary abnormalities (NCAs) in both active and/or remission period or not and to assess insulin resistance in children with FMF in both active and/or remission period of the disease compared with the control group.
The z test was used to statistically compare the differences between the rates of maternal and paternal origins in both the FMF and JIA groups.
MEFV gene defects in FMF have been well described with mutations clustering at the C-terminus and presumed to affect interactions with regulatory molecules such as 14-33 [12].
In this cross-sectional descriptive study, healthy parents of FMF patients had been evaluated about MEFV gene mutation.
My best advice to anyone who is interested in serving in the FMF is to educate yourself through our community detailers.
Increased sympathetic activity and delayed HRR response due to insufficient vagal reactivation have been shown as autonomic dysfunction findings in FMF patients.