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A gene on chromosome 16p13.3 of the RetRo gene family that encodes pyrin or marenostrin, an important modulator of innate immunity, which is thought to control the inflammatory response in myelomonocytic cells at the level of the cytoskeleton.

Molecular pathology
Defects in MEFV cause Familial Mediterranean fever, both the autosomal dominant and autosomal recessive forms.


1. Familial Mediterranean fever.
2. Fetal movement felt.
3. Forced mid-expratory flow.
4. Free molecular flow.

Patient discussion about FMF

Q. Can Familial Mediterranean Fever (FMF) cause a heart enlargement? A friend of mine is suffering from FMF. its usually doesn't bother him that much and when it dose the symptoms are stomach ache and fever. he has no heart symptoms and takes no medications. his physician told him that because of the FMF he might suffer from a heart enlargement, and that he should take some oral medications daily to prevent it. how can it be?

A. This question can't be answered with a strict yes or no.
although FMF on its own can't cause heart enlargement, FMF can cause amyloidosis because of the recurrent inflammation. this may lead to enlargement of the heart which is a severe disease.
the good side is that taking medication can decrease the chance of the cardiac enlargement.

More discussions about FMF
References in periodicals archive ?
A 16-year-old boy with FMF heterozygous for M694V mutation was admitted to our hospital because of the persistence of recurrent fever attacks 3 or 4 times in a month for 3 days, accompanied by chest and abdominal pain, myalgia, arthritis of the knees, headache, and aphthous lesion on his tongue with herpes labialis, despite taking maximum dosage of colchicine (2 mg/day).
Keywords: FMF, inflammation, atherosclerosis, TCD, stroke
Herein, we report a case of coexistence of FMF and BD, and to discuss the immunopathogenetic mechanisms for possible associations among these two autoinflammatory diseases.
Of these mutations, five accounts for more than 70% of FMF cases (V726A, M694V, M694I, M680I, and E148Q) and have different frequencies in classically affected populations.
An FMF gene mutation (M694V homozygous positive) was identified.
63) The Security Assistance Team works closely with others to manage the over USD6 billion in FMF that is administered annually to recipient governments.
The frequency of FMF in the Turkish population is higher compared to the Western populations.
Supplies paid for with a mix of Pakistani national funds and FMF include:
2 Chainz, whose real name is Tauheed Epps, was announced to be part of the line-up for the FMF 2014 in September, along with Deadmau5, Phoenix, Rudimental, Hardwell, Knife Party, and Mackelmore & Ryan Lewis.
Although FMF is a clinical condition generally characterized by painful inflammatory attacks, high levels of acute-phase reactants, cytokines, and inflammation-induced proteins measured during attack-free phases in many patients suggest that inflammation still persists (4,5).