FLNC


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FLNC

A gene on chromosome 7q32-q35 that encodes filamin gamma (filamin C), a muscle-specific actin-binding protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and anchors membrane proteins to the actin cytoskeleton. It is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibres.

Molecular pathology
Defects in FLNC cause myofibrillar myopathy type 5 and myopathy distal type 4.
References in periodicals archive ?
Valls held his ground in the face of FLNC threats, saying that his government has adopted a "zero tolerance" policy with respect to organized crime and violence.
De todos es conocido que en junio de 1999 un grupo de corsos cubiertos de PASAMONTANAS dieron una conferencia de prensa para anunciar la aparicion del FLNC (Front de Liberation National de la Corse) y de su brazo armado ARMATA CORSA, que su objetivo final es liberarse del YUGO IMPERIALISTA del gobierno frances que se apodero de la isla de Corcega hace 250 anos luego de ganarsela a los genoveses en un volado
Source:RefSeq mRNA;Acc:NM_001123148] ENSSSCG00000024 694 TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa [Source:HGNC Symbol;Acc:11537] ENSSSCG00000016 409 UBE3C ubiquitin protein ligase E3C [Source:HGNC Symbol;Acc:16803] ENSSSCG00000016 578 FLNC filamin C, gamma [Source:HGNC Symbol;Acc:3756] ENSSSCG00000012 741 MAMLD 1 mastermind-like domain containing 1 [Source:HGNC Symbol;Acc:2568] ENSSSCG00000012 832 MXRA5 matrix-remodelling associated 5 [Source:HGNC Symbol;Acc:7539] Supplementary Table 4.