FLNC


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FLNC

A gene on chromosome 7q32-q35 that encodes filamin gamma (filamin C), a muscle-specific actin-binding protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and anchors membrane proteins to the actin cytoskeleton. It is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibres.

Molecular pathology
Defects in FLNC cause myofibrillar myopathy type 5 and myopathy distal type 4.
References in periodicals archive ?
FLNC gene trait is usually autosomal dominant, and the FLNC protein plays an essential role in myofibrillar development.
The level of serum CK was 812.5 U/L for Case 1 and 114.4 U/L for Case 2, similar to previous reports on FLNC myopathy patients, which was normal or slightly elevated, with the highest value less than tenfold of the normal range.[2] Both cases also showed myogenic damage by EMG, but Vorgerd et al.
Moreover, total IgG and anti-glutatione S-transferase (GST) antibody level were not altered among the patient groups, which indicate that the autoantibody response was specific for FLNC.
Valls held his ground in the face of FLNC threats, saying that his government has adopted a "zero tolerance" policy with respect to organized crime and violence.
Still, The FLNC is the most prominent such "criminal" organization in Corsica 6 founded in the mid-1970s as a separatist movement, the group has attacked and bombed mainland targets for decades.
!Ademas del Partitu Corsu d'Azione, el FLNC y ARMATA CORSA, podemos mencionar el Partie Autonomiste d'Alsace de la etnia alsaciana, el Strollad Emernerien Vreiz de la etnia bretona o el Vaamasch Verbond van Frankrijk de la tradicionalmente doblegada etnia flamenca!
!Respeto a los acuerdos de Matignon firmados por el FLNC y el primer ministro de Francia!