FLNA

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FLNA

A gene on chromosome Xq28 that encodes filamin A, an actin-binding protein which crosslinks actin filaments, binding them to membrane glycoproteins. Filamin A is involved in remodelling the cytoskeleton to effect changes in cell shape and migration; it interacts with integrins, transmembrane receptor complexes and second messengers.

Molecular pathology
Defects in FLNA cause:
• Cardiac valvular dysplasia X-linked;
• Frontometaphyseal dysplasia;
• Melnick-Needles syndrome;
• Otopalatodigital syndromes types 1 and 2;
• Periventricular nodular heterotopia types 1 and 4; and
• Terminal osseous dysplasia.
Defects may also cause macrothrombocytopaenia.
References in periodicals archive ?
Morgan--winner of a Pulitzer prize in journalism--offers keen journalistic insight in his book, discussing how torture for information affects both the terrorist as well as the person inflicting the harm, and addressing both his involvement in brutal acts and the way he psychologically justified what he calls unimaginable barbarities, He also includes an insightful discussion of the FLN tactic of enforcing Islamic morals as a means of controlling neighborhoods in Algiers.
Things have improved since an early 2014 conflict over Bouteflika's health problem, thanks to better organisation of his entourage, the powerful armed forces, the military intelligence agency DRS and the FLN. From Bouteflika's perspective, this is thanks to his younger brother/physician, Dr Said, an exceptionally intelligent but corrupt figure who is controversial, PM AbdelMalek Sellal and FLN Secretary-General Amar Sa'dani.
The FLN was primarily an anticolonial, nationalist movement in which the Islamic religion played only a secondary role.
Through it the paratroopers had procured information that had saved thousands of innocent civilians from FLN bombers.
Boutaflika managed to side-line even the moderate Islamists, such as Belkhadem whom he dismissed as PM in June 2008 and got him replaced by a secular and reformist figure, Ahmed Ouyahia, secretary-general of the RND which is the main junior coalition partner of the president's FLN. By then, Bouteflika had enlarged his power base and secured an overwhelming majority of both the National Assembly and the senate with his coalition consisting of the FLN, the RND and the Mouvement Pour la Reforme Nationale (MRN).
The FLN now has a total of 39 seats, down from its previous 56 in the 144-seat upper house.
Opposition to the reforms came from several sectors (FLN party, unions, communists, and intellectuals).
Revenant sur la candidature de Bouteflika pour un nouveau mandat, Bouchareb a precise que le FLN, dont le candidat est president, ne pouvait lui denier ce droit.
On Bouteflika's demand, the Central Committee of le Front de Liberation Nationale (FLN) on Jan.
Le FLN et le RND ont reagi, ce lundi , a la lettre du president de la Republique adressee, dimanche dernier, a l'occasion du depot du dossier de sa candidature au Conseil constitutionnel, lue en son nom par son directeur de campagne, Abdelghani Zaalane.
Backed by secretive military and intelligence establishments, President Abdelaziz Bouteflika controls the ruling National Liberation Front (FLN) which for many years has maintained a doctrinaire and resource nationalist regime.