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Considering significant differences between the in vitro and in vivo models of drug actions on adipocytes, subsequent in vivo studies with olanzapine and specific FLAP inhibitors are required to evaluate the significance of our in vitro observations.
The direct 5-LOX inhibitors interact with the enzyme via a redox, a nonredox or an iron chelating mechanism (McMillan and Walker, 1992), while FLAP inhibitors block the association of the enzyme with the cellular membrane (Dixon et al., 1990).