KLF11

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KLF11

A gene on chromosome 2p25 that encodes a zinc finger transcription factor that binds SP1-like sequences in epsilon- and gamma-globin gene promoters, inhibiting cell growth and causing apoptosis.

Molecular pathology
KLF11 mutations are linked to maturity-onset diabetes of the young (type 7).

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Zhang and Wu have found out that stimulating the gene expression of [gamma]-globin, EpoR, Spi, and FKLF, while hindering the gene expression of Ckit, GATA1, and GATA2, could promote the [gamma]-globin gene expression and alter the expression of gene which is responsible for the regulation of [gamma]-globin gene expression and the expression of other genes that are participated in the survival, proliferation, and terminal differentiation of erythroid cells [76].

Natural remedies for the treatment of beta-thalassemia and sickle cell anemia--current status and perspectives in fetal hemoglobin reactivation

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