FOXO3

(redirected from FKHRL1)

FOXO3

A gene on chromosome 6q21, which encodes a member of the forkhead family of transcription factors, which is thought to act as a trigger for apoptosis.
   
Molecular pathology
A translocation of FOXO9 with MLL is associated with secondary acute leukaemia.
References in periodicals archive ?
Arteaga, "Transforming growth factor [beta] enhances epithelial cell survival via Akt-dependent regulation of FKHRL1," Molecular Biology of the Cell, vol.
FOXO3A, also known as forkhead in rhabdomyosarcoma-like protein 1 (FKHRL1), is a transcription factor with important roles in embryonic development, differentiation, and tumorigenesis [1].
The alternate names FKHR, FKHRL1, and AFX have been used for FOXO1, FOXO3, and FOXO4, respectively [35].
Vlassara, "AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation," American Journal of Physiology-Cell Physiology, vol.
Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int 2003; 64:1189-1198.
NGF/TrkA signaling leads to the PI3K/Akt/ FKHRL1 pathway, that governs the cell survival and the mitogen activated protein kinase (MAPK) pathway that controls cell mitosis (11-13).
Proteins were separated by SDS-PAGE, blotted onto nitrocellulose membrane and probed with the antibodies dilution recognizing: Akt 1:1000, PAkt (Thr 308) 1:1000, FKHRL1 1:500, MAPKs p44/42 1:1000, P38 1:1500, JNK 1:2000 anti-[beta]-actin; all at 1:1000 dilution (cell signaling technology).
Members of the forkhead box O (Foxo) family of transcription factors, including Foxo1 (previously described as FKHR), Foxo3a (FKHRL1), Foxo4 (AFX), and Foxo6, are phosphorylated by insulin/IGF-1 through a PI3K/Akt-dependent pathway and excluded from nucleus to inhibit their transcriptional activity (Accili et al., 2004).
Insulin-like growth factor-l-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-l-induced survival of cultured hippocarnpal neurons.
Kramers et al., "Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PKj cells result in phosphorylation of FKHR and FKHRL1," Kidney International, vol.
Kramers et al., "Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK 1 cells result in phosphorylation ofFKHR and FKHRL1," Kidney International, vol.
Lo, "Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins," Molecular Endocrinology, vol.