FOXO1

(redirected from FKHR)
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FOXO1

The gene on chromosome 13q14.1 which encodes a forkhead family transcription factor that regulates cell responses to oxidative stress. In the presence of KIRT1, it downregulates cyclin D1 and upregulates CDKN1B as required for cell transition from proliferation to quiescence. It may play a role in myogenic growth and differentiation.

Molecular pathology
FOXO1 translocation with PAX3 has been associated with alveolar rhabdomyosarcoma.
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References in periodicals archive ?
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms.
Two novel phosphorylkation sites on FKHR that are critical for its nuclear exclusion.
Accili, "Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway," The Journal of Biological Chemistry, vol.
Members of the forkhead box O (Foxo) family of transcription factors, including Foxo1 (previously described as FKHR), Foxo3a (FKHRL1), Foxo4 (AFX), and Foxo6, are phosphorylated by insulin/IGF-1 through a PI3K/Akt-dependent pathway and excluded from nucleus to inhibit their transcriptional activity (Accili et al., 2004).
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway.
Accili, "Insulin regulation of gene expression through the forkhead transcription factor foxol (Fkhr) requires kinases distinct from Akt," Biochemistry, vol.
The loss of their phosphatase activity prevents the dephosphorylation of phosphatidylinositol-3,4,5-trisphosphate to phosphatidylinositol-4,5-bisphosphate, which then allows the transfer of phosphate molecule to PDK1 and AKT proteins, allowing the activation of MDM2, GSK3, P27, P21, CASP9, BAD, FKHR, IKK, and MTOR genes (Figure 1).
(105) The 2 most common translocations involve FKHR gene (FOXO1A) on 13q14, and either Pax3 (2q35) or Pax7 (1p36) genes.
Unterman, "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting," Biochemical Journal, vol.