HNF1B

(redirected from FJHN)
Also found in: Acronyms.

HNF1B

A gene on 17q12 that encodes a transcription factor that binds an inverted palindromic sequence of DNA.

Molecular pathology
Defects in HNF1B are a cause of maturity-onset diabetes of the young type 5 (MODY5, or renal cysts and diabetes syndrome) and contribute to the development of type-2 diabetes and prostate cancer hereditary type 11.
References in periodicals archive ?
Familial juvenile hyperuricaemic nephropathy (FJHN): linkage analysis in 15 families, physical and transcriptional characterisation of the FJHN critical region on chromosome 16p11.
Homozygosity for uromodulin disorders: FJHN and MCKD-type 2.
The uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect.