RETN

(redirected from FIZZ3)

RETN

A gene on chromosome 19p13.2 that encodes resistin, which is secreted by adipocytes and suppresses insulin-driven glucose uptake by adipose cells.

Molecular pathology
RETN mutations may link obesity to type-2 diabetes.
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References in periodicals archive ?
Resistin is a cysteine-rich protein of 12.5 kDa also known as adipocyte-secreted factor (ASF) or "found in inflammatory zone 3" (FIZZ3) [103].
Resistin is also known as ADSF (adipocyte-secreted factor) or FIZZ3 (found in inflammatory zone 3).
Juliar et al., "Serum resistin (FIZZ3) protein is increased in obese humans," Journal of Clinical Endocrinology and Metabolism, vol.
Klenk et al., "Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator--activated receptor-y action in humans," Diabetes, vol.
Resistin, also known as found in inflammatory zone 3 (FIZZ3) is an adipocyte-derived hormone known to promote insulin resistance, impair adipocyte differentiation, and to promote inflammation [1-5] and that was originally identified in rats as a protein secreted by adipocytes that is under the control of different humoral signals and nutritional status; nutrition and metabolism regulate this adipoine.
The third homolog, FIZZ3, is known as resistin or adipocyte-specific secretory factor and is identical to the fat specific homolog (119).