EpICD combines with FHL2
, [beta]-cathenin and Lef proteins inside the nucleus.
Among the CpGs significantly associated with [DELTA]age and aging rate (Bonferroni corrected P <0.05), we identified 3 CpGs associated with urinary 1-OH-pyrene levels (located on FHL2
and BOK; P <0.05), and 6 CpGs associated with 9-OH-phenanthrene levels (located on ELOVL2, TR1M59, ACSS3, RNF170, and 3q25.31; P<0.05) (Table S6).
, DUSP27, and ORAOV1 in an 8-CpG blood-based model reporting
Recently, PPAR[beta]/[delta] was identified as a target gene of FHL2
, a tumor suppressor gene also involved in hepatocellular carcinoma [119, 120].
Noma et al., "FHL2
prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2," FASEB Journal, vol.
Based on motif analysis of PAX5, we searched out 28 PAX5 target genes, that is, BAX, BCL2, BLK, CCND1, CD19, D79A, CDKN1A, FCER2, FHL2
, LEF1, MET, MMP1, MYCNA, PRDM1, PRKCE, RAG2, RB1, TIMP1, TP53, XBP1, EGR1, ESR1, ELK1, ETS1, KCNH4, VPREB1, IGLL1, and KCNH8.
A total of 124 DEGs (e.g., POLA2, TMED7, SLC25A24, NF2, and COL4A2) were significantly enriched in "lymphocyte TarBase pathway" (P value = 9.35 x [10.sup.-16]), while 28 DEGs (e.g., NCOR2, DSTN, RAC1, PIK3R1, and FHL2
) were significantly enriched in "androgen receptor signaling pathway" (P value = 9.12 x [10.sup.-7]).
Lin et al., "Deletion of FHL2
gene impaired ischemia-induced blood flow recovery by modulating circulating proangiogenic cells," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
As can be expected, these genes can be assigned to different functional groups such as cell death regulators (CASP2, ING2, MDM4, NAIP), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, P0LR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), oxidative stress response (SPATS2L, GSTT2B, NQO1), DNA maintenance and processing (BAHCC1, FANCA, H1ST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), blood coagulation (FGA, MATR3, PROCR, P1K3CG), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2
, P1K3CG, RALB, T1CAM2), cytoskeletal components (BCL7A, DYNC1LI2, SEPT10, SEPT11), transport functions (ABCC1, FXYD2, S100A6, SCNN1G, XP05), or others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
Methylation was detected at genes regarded in the literature as "aging genes" including the FHL2
gene and the ELOVL2 gene.
encodes mutations in the perforin (PFR1) gene.
Golomb et al., "FHL2
switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy," International Journal of Cardiology, vol.