FGFR3


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FGFR3

A gene located on chromosome 4p16.3, which encodes fibroblast growth-factor receptor 3, one of the mitogenic signalling molecules with roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development.

Molecular pathology
Mutations are linked to achondroplasia, craniosynostosis and multiple forms of skeletal dysplasia. It is up-regulated in cell transformation and some cancers.
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Luminal UC was enriched with papillary morphology, FGFR3 mutations, and erb-b2 receptor tyrosine kinase 2 (ERBB2) amplifications, and their gene expression profiles were controlled by peroxisome proliferator activator receptor [gamma] (PPAR[gamma]).
Bladder Cancer in the Genomic Era
Activating mutations of FGFR3, which have an effect on the negative regulation of cartilage growth are encountered in hypochondroplasia and achondroplasia (10).
Evaluation of Efficacy of Long-term Growth Hormone Therapy in Patients with Hypochondroplasia
One research recently further demonstrated that FGFR3 was targeted by miR-243p in multiple myeloma [16].
miR-24-3p/FGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression
The results confirmed that alterations involving RB1 and NFE2L2 were enriched in basal cancers, whereas alterations involving FGFR3 and KDM6A were enriched in luminal tumors [41].
Update on the Treatment of Metastatic Urothelial Carcinoma
PCR amplification of exons 7,10, 13, 15 and 19 of FGFR3 was performed.
A CASE WITH HETEROZYGOTE N540K HYPOCHONDROPLASIA-CLINICAL FEATURES
She was admitted to the neonatal ward for investigation of a suspected dysmorphic syndrome and initial FGFR3 molecular genetic testing for achondroplasia revealed no mutations.
Costello Syndrome and Umbilical Ligament Rhabdomyosarcoma in Two Pediatric Patients: Case Reports and Review of the Literature
The poor prognosis of patients with t(4; 14) may be in part due to its association with upregulation of the fibroblast growth factor receptor 3 (FGFR3).
The Evolution of Prognostic Factors in Multiple Myeloma
(iii) In Figure 1, "Pgfr" should be corrected to "Fgfr3," and "Chrdl" should be corrected to "Chrdl1." The corrected figure is shown below.
Corrigendum to "Fish Collagen Promotes the Expression of Genes Related to Osteoblastic Activity"
When SCs robustly proliferate, the expression level of Fgf20 and Fgfr3 decreases [67].
Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation
This translocation results in increased expression of fibroblast growth factor receptor 3 (FGFR3) and multiple myeloma SET (MMSET) domain [11, 12].
Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review
Zeng et al., "mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis," Osteoarthritis and Cartilage, vol.
MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis
(9,16) El sindrome de Crouzon esta relacionado especificamente con el gen FGFR2 en el cromosoma 10q26; algunos pacientes pueden presentar manifestaciones dermatologicas de acantosis nigricans (AN) vinculando al gen FGFR3. (8,9,13,15,16)
Sindrome de Crouzon: Revision de tema y reporte de caso

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