FGFR4

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FGFR4

A gene on chromosome 5q35.1-qter that encodes fibroblast growth factor receptor-4, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The function of FGFR4 is unknown.

Molecular pathology
FGFR4 is overexpressed in gynaecological tumours, suggesting a role in breast and ovarian malignancies.
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References in periodicals archive ?
The FGFR tyrosine kinase family consists of four kinases: FGFR-1, FGFR-2, FGFR-3 and FGFR-4. These function as cell surface receptors for fibroblast growth factors, playing a critical role in embryonic development, cell proliferation, differentiation, and migration control.
FGFR3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung.
Four genes have been identified that encode distinct high affinity ([K.sub.d] = [10.sup.-11] mol/L) receptors for FGFs, fibroblast growth factor receptor 1 (FGFR-1), FGFR-2, FGFR-3, and FGFR-4 (175).