FGF9


Also found in: Acronyms.

FGF9

A gene on chromosome 13q11-q12 that encodes fibroblast growth factor 9 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF9 is produced mainly by neurons and may be important for glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumours. FGF9 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF9 cause multiple synostoses syndrome type 3.
References in periodicals archive ?
Flechas indican regulacion morfogenetica de DHH, PDGFA, activina A, FGF2 y FGF9. Barra 20 [micro]m.
The primers used in this study were as follows: Igf1, 5'-ACAGGCTATGGCTCCAGCAT-3' and 5'-GCTCCGGAAGCAACACTCA-3'; Fgf1, 5'-GCGGGCGAAGTGTATATAAAGG-3' and 5'-CGGTGTCCATGGCCAAGT-3'; Fgf2, 5'-CA ACCGGTACCTTGCTATGA-3' and 5'-TCCGTG ACCGGTAAGTATTG-3'; Fgf9, 5'-CTATCCAG GGAACCAGGAAAGA-3' and 5'-CAGGCCCA CTGCTATACTGATAAA-3'; Fgf18, 5'-GAATT CTACCTGTGTATGAACCGAAA-3' and 5' -TG AACACGCACTCCTTGCTAGT-3 '; Igfbp3, 5 ' -CACATCCCAAACTGTGACAA-3 ' and 5'-CCA TACTTGTCCACACACCA-3'; and Rplp0 (internal control), 5'-CGACATCACAGAGCAGGC-3' and 5'-CACCGAGGCAACAGTTGG-3'.
1.73 Down TGF-alpha CXCL10 Chemokine (C-X-C motif) ligand 10, 1.57 Down IP10 FASLG Fas ligand (TNF superfamily, member 1.61 Down 6), FasL(TNFSF6) 1L1RAP Interleukin 1 receptor accessory 1.85 Down protein RUNX2 Runt-related transcription factor 2 1.7 Up FGF9 Fibroblast growth factor 9 1.69 Up (glia-activating factor) * Fold-change from baseline was significant at p < 0.05.
En el primero se sometio a estres social a las ratas durante semana y media, posteriormente se observo que sus niveles de FGF9 aumentaron.
Fgf9 is initially secreted from gamma delta T cells, an unconventional, rare subset of T cells involved in the immune response.
It is not completely understood to what extent Fgf8 regulates the odontogenic potential of the dental epithelium, as Fgf8-/mice lack molars and have developed incisors; it is possible FGF9 rescues the incisor development when FGF8 is not present [Zhang et al., 2005; Pani, 2011].
Past work from his own lab and others suggested that FGF9, a close chemical cousin of FGF20, might also participate in kidney development.
"FGF9 seemed to 'awaken' the supporting cells and stimulated their wrapping around the otherwise fragile blood vessel wall," said Canadian researcher Matthew Frontini, from the University of Western Ontario.
Researcher Matthew Frontini, from the University of Western Ontario, said yesterday: "FGF9 seemed to 'awaken' the supporting cells and stimulated their wrapping around the otherwise fragile blood vessel wall.
Ana temel protein (MBP) gibi eozinofil granul urunleri epitelyum hiperplazisini tesvik etmek icin fibroblast buyume faktor 9'u (FGF9) artirabilir ve transforming buyume faktor-[beta]1 (TGF-[beta]1) gibi pro-fibrotik faktorlerin eozinofillerden salgilanmasi subepitelyal fibroza sebep olabilir (15).
Moreover, several signaling molecules, such as Shh, FGF4, FGF9, BMP4, and BMP7, as well as Wnt10a/b, are restrictedly expressed in the enamel knot.
Using two different transgenic Cre mouse lines that induce either a temporal or a cell-specific ablation of this receptor reveal that FGFR2 mediated FGF9 signaling is essential for proliferation and Sertoli differentiation during testis determination (16).