FGF9

Also found in: Acronyms.

FGF9

A gene on chromosome 13q11-q12 that encodes fibroblast growth factor 9 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF9 is produced mainly by neurons and may be important for glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumours. FGF9 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF9 cause multiple synostoses syndrome type 3.

Mentioned in ?

multiple synostoses syndrome type 3

References in periodicals archive ?

Flechas indican regulacion morfogenetica de DHH, PDGFA, activina A, FGF2 y FGF9. Barra 20 [micro]m.

Epithelial-Mesenchymal Transitions in the Development of Testis/Interacciones Epitelio-Mesenquimaticas en el Desarrollo Testicular

The primers used in this study were as follows: Igf1, 5'-ACAGGCTATGGCTCCAGCAT-3' and 5'-GCTCCGGAAGCAACACTCA-3'; Fgf1, 5'-GCGGGCGAAGTGTATATAAAGG-3' and 5'-CGGTGTCCATGGCCAAGT-3'; Fgf2, 5'-CA ACCGGTACCTTGCTATGA-3' and 5'-TCCGTG ACCGGTAAGTATTG-3'; Fgf9, 5'-CTATCCAG GGAACCAGGAAAGA-3' and 5'-CAGGCCCA CTGCTATACTGATAAA-3'; Fgf18, 5'-GAATT CTACCTGTGTATGAACCGAAA-3' and 5' -TG AACACGCACTCCTTGCTAGT-3 '; Igfbp3, 5 ' -CACATCCCAAACTGTGACAA-3 ' and 5'-CCA TACTTGTCCACACACCA-3'; and Rplp0 (internal control), 5'-CGACATCACAGAGCAGGC-3' and 5'-CACCGAGGCAACAGTTGG-3'.

The Window of implantation is closed by Estrogen via insulin-like growth factor 1 pathway

1.73 Down TGF-alpha CXCL10 Chemokine (C-X-C motif) ligand 10, 1.57 Down IP10 FASLG Fas ligand (TNF superfamily, member 1.61 Down 6), FasL(TNFSF6) 1L1RAP Interleukin 1 receptor accessory 1.85 Down protein RUNX2 Runt-related transcription factor 2 1.7 Up FGF9 Fibroblast growth factor 9 1.69 Up (glia-activating factor) * Fold-change from baseline was significant at p < 0.05.

Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study

En el primero se sometio a estres social a las ratas durante semana y media, posteriormente se observo que sus niveles de FGF9 aumentaron.

Descubren otra causa de la depresion: proteinas factor de crecimiento de fibroplastos

Fgf9 is initially secreted from gamma delta T cells, an unconventional, rare subset of T cells involved in the immune response.

Why humans don't regenerate hair after wounding

It is not completely understood to what extent Fgf8 regulates the odontogenic potential of the dental epithelium, as Fgf8-/mice lack molars and have developed incisors; it is possible FGF9 rescues the incisor development when FGF8 is not present [Zhang et al., 2005; Pani, 2011].

Molecular factors resulting in tooth agenesis and contemporary approaches for regeneration: a review

Past work from his own lab and others suggested that FGF9, a close chemical cousin of FGF20, might also participate in kidney development.

How embryonic kidneys maintain supply of stem cells

"FGF9 seemed to 'awaken' the supporting cells and stimulated their wrapping around the otherwise fragile blood vessel wall," said Canadian researcher Matthew Frontini, from the University of Western Ontario.

AN electronic nose has been [...]

Researcher Matthew Frontini, from the University of Western Ontario, said yesterday: "FGF9 seemed to 'awaken' the supporting cells and stimulated their wrapping around the otherwise fragile blood vessel wall.

SUPPORT ACT COULD BE STAR IN CUTTING TOLL OF HEART ATTACKS AND STROKES

Ana temel protein (MBP) gibi eozinofil granul urunleri epitelyum hiperplazisini tesvik etmek icin fibroblast buyume faktor 9'u (FGF9) artirabilir ve transforming buyume faktor-[beta]1 (TGF-[beta]1) gibi pro-fibrotik faktorlerin eozinofillerden salgilanmasi subepitelyal fibroza sebep olabilir (15).

Eosinophilic esophagitis/Eozinofilik ozofajit

Moreover, several signaling molecules, such as Shh, FGF4, FGF9, BMP4, and BMP7, as well as Wnt10a/b, are restrictedly expressed in the enamel knot.

The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal

Using two different transgenic Cre mouse lines that induce either a temporal or a cell-specific ablation of this receptor reveal that FGFR2 mediated FGF9 signaling is essential for proliferation and Sertoli differentiation during testis determination (16).

Role of postnatal expression of Fgfr1 and Fgfr2 in testicular germ cells on spermatogenesis and fertility in mice