In addition, SHH and FGF8
when administered simultaneously induce the expression of dopamine-related proteins [38, 39].
is required for outgrowth and patterning of the limbs," Nature Genetics, vol.
is expressed during specific phases of rodent oocyte and spermatogonium development.
In addition, neurotrophic factors such as SHH and FGF8
have been known to be critical for the specification and development of a neuronal subtype [29, 30].
A proportion of mice with a heterozygous disruption of their FGF8
gene showed a less severe phenotype than did those with a homozygous disruption, and the former phenotype was observed in the first branchial arch on only one side of the head .
Armfield and colleagues zeroed in on two proteins, BMP4 (Bone Morphogenetic Protein 4) and FGF8
(Fibroblast Growth Factor 8).
One of the FGF family, polymorphisms in the FGF8
is associated with carcass quality, growth and feed efficiency in beef cattle (Moore and Marques, 2008).
over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease," Oncogene, vol.
Recientemente se reporto la expresion de FGF8
, un factor de crecimiento involucrado en el desarrollo embrionario de la union miotendinosa, en condilos de ratas, pero no se ha demostrado su secrecion por parte del musculo esqueletico (56, 57) (tabla 2).
Shh expression occurs downstream of Fgf8
and Fgf9, is regulated by Bmp4, and is responsible for regulating Bmp2 [Zhao et al., 2000; Thesleff et al., 2001].