FGF8


Also found in: Acronyms.

FGF8

A gene on chromosome 10q24 that encodes fibroblast growth factor 8 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF8 is expressed in adults only in the testes and ovaries; it is required for normal brain, eye, ear and limb development during embryogenesis, and for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. FGF8 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF8 cause Kallmann syndrome type 6.
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References in periodicals archive ?
In addition, SHH and FGF8 when administered simultaneously induce the expression of dopamine-related proteins [38, 39].
Capecchi, "Fgf8 is required for outgrowth and patterning of the limbs," Nature Genetics, vol.
FGF8 is expressed during specific phases of rodent oocyte and spermatogonium development.
In addition, neurotrophic factors such as SHH and FGF8 have been known to be critical for the specification and development of a neuronal subtype [29, 30].
A proportion of mice with a heterozygous disruption of their FGF8 gene showed a less severe phenotype than did those with a homozygous disruption, and the former phenotype was observed in the first branchial arch on only one side of the head [15].
Armfield and colleagues zeroed in on two proteins, BMP4 (Bone Morphogenetic Protein 4) and FGF8 (Fibroblast Growth Factor 8).
One of the FGF family, polymorphisms in the FGF8 is associated with carcass quality, growth and feed efficiency in beef cattle (Moore and Marques, 2008).
Leung, "FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease," Oncogene, vol.
Recientemente se reporto la expresion de FGF8, un factor de crecimiento involucrado en el desarrollo embrionario de la union miotendinosa, en condilos de ratas, pero no se ha demostrado su secrecion por parte del musculo esqueletico (56, 57) (tabla 2).
Shh expression occurs downstream of Fgf8 and Fgf9, is regulated by Bmp4, and is responsible for regulating Bmp2 [Zhao et al., 2000; Thesleff et al., 2001].