FGF8


Also found in: Acronyms.

FGF8

A gene on chromosome 10q24 that encodes fibroblast growth factor 8 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF8 is expressed in adults only in the testes and ovaries; it is required for normal brain, eye, ear and limb development during embryogenesis, and for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. FGF8 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF8 cause Kallmann syndrome type 6.
References in periodicals archive ?
Here, the pattern was different: FGF8 is present in the back part of the jaw, but BMP4 is present along the entire length of the jaw, including where FGF8 is found.
Pitx2 activates Dlx2, is involved in a positive feedback loop with FGF8, and is required for the regulation and orientation of tooth development [Zhang et al.
Myxoinflammatory fibroblastic sarcomab Deregulation of FGF8 and NPM3 Myxoid/round cell liposarcoma FUS-DDIT3 EWSR1-DDIT3 Pericytoma with t(7;12) ACTB-GLI1 Solitary fibrous tumor/ Unknown hemangiopericytoma Synovial sarcoma SS18-SSX1 SS18-SSX2 SS18-SSX4 SS18L1-SSX1 Abbreviation: pPNET, peripheral primitive neuroectodermal tumor; ?