FGF2


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FGF2

A gene on chromosome 4q26 that encodes fibroblast growth factor 2 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration. FGF2 plays a key role in various processes, including limb and nervous system development, wound healing and tumour growth, as well as angiogenesis. It is expressed in normal ovarian tissue and in hepatocellular carcinoma, but not in normal liver cells. FGF2 interacts with FGF receptors FGFR1, -2, -3 and -4.
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* Lyophilized authentic human Polypeptide Growth Factors: Adiponectin, BMP2, EGF, FGF1, FGF2, FGF7, FGF10, Fallistatin, Gremlinl, hGH, hPL, Irisin, Midkine, PDGF, PRL, SCF, TGFb1, TGFb3, TIMP2, Thymosin-b4, VEGF, VIP
Taking into account the sequences recently published by the National Center for Biotechnology Information (NCBI) and the data base of the bovine genome sequence, specific primers were designed in order to amplify bovine gene coding regions GDF9, BMP15, FGF2, TGF[beta]-R1, BMPR-IB and FGFR2 using the online software Primer-BLAST and Integrated DNA Technologies (IDT) (Table 1).
Its alternatively spliced isoform FGFR2-IIIc, predominantly expressed in cells of the mesenchymal lineage, usually binds other members of the FGF family, such as FGF1 and FGF2 [20].
We further measured the mRNA levels of the epithelial stem cell marker (ABCG2) and proangiogenic/inflammatory cytokines (FGF2, IL-1[beta], and IL-6) in the cornea by real-time RT PCR [18].
Bernard and her co-author Debrup Chakraborty, a postdoctoral student in her lab, studied mice that were fed a high-fat diet and discovered that this higher-risk layer of fat produced larger amounts of the fibroblast growth factor-2, or FGF2, protein when compared to the subcutaneous fat.
Embryonic stem cells release EGF, SCF, LIF, FGF2, TGF-[beta], and IGF (25,29), which are known to support IVM of oocytes.
Vascular endothelial growth factor and fibroblast growth factor-2 (FGF2), two growth factors that act at multiple points in angiogenesis, are among the most studied angiogenic factors.
Purification of recombinant proteins: Recombinant LIF, FGF2 and FGF9 (rLIF, rFGF2 and rFGF9, respectively) were prepared as described in a previous report (12).
For maintenance culture, H9 cells were maintained on inactivated murine embryonic fibroblasts in DMEM/F12 medium supplemented with 20% serum replacement, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), L-glutamine, non-essential amino acids, [beta]-mercaptoethanol (all purchased from Gibco) and fibroblast growth factor 2 (FGF2) (Invitrogen).
These results support that controlling the aberrant expression of TGF-[beta]1 and FGF2 via inhibition of Wnt/[beta]-catenin signaling could serve as a potential therapeutic strategy for PF [71].