FGF12

FGF12

A gene on chromosome 3q28 that encodes fibroblast growth factor 12 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF12’s function is unknown; it lacks the N-terminal signal sequence found in most other FGF family members, but has clusters of basic residues which act as a nuclear localisation signal. It is highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and segmentally in the body wall. It is thought to play a role in nervous system development and function.
References in periodicals archive ?
Bagordakis et al., "Polymorphisms in FGF12, VCL, CX43 and VAX1 in Brazilian patients with nonsyndromic cleft lip with or without cleft palate," BMC Medical Genetics, vol.
Increased genes included EGFR, FGF12, AKT3, and CTNNA3 (Figure 3(c), Table 1).
Meineke, "Involvement of intracellular expression of FGF12 in radiation-induced apoptosis in mast cells," Journal of Radiation Research, vol.
Term Count P value Genes MAPK signaling pathway 13 0.0062 RPS6KA5, AKT1, MAP4K4, MAP3K5, PLA2G4A, DUSP2, FGF9, TGFBR1, MAP2K4, MKNK2, PPP3R1, FGF12, DUSP6 Endocytosis 10 0.010 IGF1R, ADRB3, FLT1, TGFBR1, PSD3, VPS4B, DNAJC6, PSD2, ARAP2, LDLRAP1 Axon guidance 7 0.042 EPHA5, SEMA6A, PLXNA1, PPP3R1, SEMA4C, L1CAM, SRGAP1 Insulin signaling 6 0.0076 AKT1, L1CAM, IGF1R, IRS2, pathway SOCS7, RHOQ Focal adhesion 4 0.021 VCAM1, L1CAM, ITGA4, CERCAM Table 2: Small molecules which might reverse the dysregulation of AD in EC and HIP regions.