FGF12A gene on chromosome 3q28 that encodes fibroblast growth factor 12 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF12’s function is unknown; it lacks the N-terminal signal sequence found in most other FGF family members, but has clusters of basic residues which act as a nuclear localisation signal. It is highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and segmentally in the body wall. It is thought to play a role in nervous system development and function.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.