FGF10


Also found in: Acronyms.

FGF10

A gene on chromosome 5p13-p12 that encodes fibroblast growth factor 10 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. Its name notwithstanding, FGF10 is mitogenic for keratinocytes but has little effect on fibroblasts; FGF10 interacts with FGF receptors FGFR1 and -2.

Molecular pathology
Defects in FGF10 cause autosomal dominant aplasia of lacrimal and salivary glands and lacrimo-auriculo-dento-digital syndrome (LADDS).
References in periodicals archive ?
* Lipid Bilayer-based Carriers loaded with Polypeptide Growth Factors: sh-Oligopeptide-1 (EGF), -4(Thymosin-b4); sh-Polypeptide-1 (FGF2), -3(FGF7), -4(SCF), -5(TGFb3), -7(hGH), -9(VEGF), -10(FGF10), -11(FGFl), -15(TIMP2), -22(TGFbl), -28(PRL), -40(hPL), -59(PDGF), -71 (VIP), -78(HSP90A), -93(CTGF), -101 (Adiponectin)
Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.
Govindarajan et al., "FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development," Development, vol.
FGF3 and FGF10 have some form of functional redundancy, as Fgf3-/- or Fgf10-/- mice develop teeth normally, but mice that lack the FgfR2b receptor (the receptor for Fgf3 and Fgf10) exhibit teeth that arrest at the bud stage [Zhang et al., 2005].
Por ejemplo, en una etapa posterior a la migracion e induccion de las CNCC, la interaccion de Shh con el factor de crecimiento fibroblastico 10 (FGF10) afecta la transformacion epitelio-mesenquima, proceso clave en la produccion de la fisura labiopalatina.
Washington, July 16 (ANI): Scientists at the Salk Institute for Biological Studies have found that a growth factor called Fgf10 helps keep the brain's development on track.
Human lung fibroblasts were exposed to various concentrations of 2,4-D, MCPA, FGF 1, FGF6 and FGF10. Two controls were used: no cells, and solvent solution.
FGF2 and FGF10 are also expressed in adipose tissue and have each been implicated in adipogenesis.
The FGF10 is firstly expressed in the formative period of mammary line and regulates FGFR2b to affect Wnt10 response to the development of the mammary line.
Stijn De Langhe, Ph.D., and his colleagues reported that destruction of lung tissue in mice induces smooth muscle cells surrounding the airways to secrete a protein known as fibroblast growth factor 10 (FGF10), which induces surviving epithelial cells in the airways to revert to a stem-cell state, proliferate, repair and repopulate the lining of die lungs.