FGF10


Also found in: Acronyms.

FGF10

A gene on chromosome 5p13-p12 that encodes fibroblast growth factor 10 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. Its name notwithstanding, FGF10 is mitogenic for keratinocytes but has little effect on fibroblasts; FGF10 interacts with FGF receptors FGFR1 and -2.

Molecular pathology
Defects in FGF10 cause autosomal dominant aplasia of lacrimal and salivary glands and lacrimo-auriculo-dento-digital syndrome (LADDS).
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* Lipid Bilayer-based Carriers loaded with Polypeptide Growth Factors: sh-Oligopeptide-1 (EGF), -4(Thymosin-b4); sh-Polypeptide-1 (FGF2), -3(FGF7), -4(SCF), -5(TGFb3), -7(hGH), -9(VEGF), -10(FGF10), -11(FGFl), -15(TIMP2), -22(TGFbl), -28(PRL), -40(hPL), -59(PDGF), -71 (VIP), -78(HSP90A), -93(CTGF), -101 (Adiponectin)
Reverse-Aging Biotechnology Regeron
Fgf10 has been reported to participate in adipogenesis.
Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL/6J x Kunming F2 Mice Population Using Genome-Wide Association Study
Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.
Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome
Govindarajan et al., "FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development," Development, vol.
Ocular surface development and gene expression
FGF3 and FGF10 have some form of functional redundancy, as Fgf3-/- or Fgf10-/- mice develop teeth normally, but mice that lack the FgfR2b receptor (the receptor for Fgf3 and Fgf10) exhibit teeth that arrest at the bud stage [Zhang et al., 2005].
Molecular factors resulting in tooth agenesis and contemporary approaches for regeneration: a review
Por ejemplo, en una etapa posterior a la migracion e induccion de las CNCC, la interaccion de Shh con el factor de crecimiento fibroblastico 10 (FGF10) afecta la transformacion epitelio-mesenquima, proceso clave en la produccion de la fisura labiopalatina.
Analisis molecular de Sonic Hedgehog (SHH) en la etiologia de la fisura labiopalatina no sindromica en trios caso-progenitores chilenos
Washington, July 16 (ANI): Scientists at the Salk Institute for Biological Studies have found that a growth factor called Fgf10 helps keep the brain's development on track.
Growth factor that keeps brain development on track identified
Human lung fibroblasts were exposed to various concentrations of 2,4-D, MCPA, FGF 1, FGF6 and FGF10. Two controls were used: no cells, and solvent solution.
Effect of fibroblast growth factors and chlorophenoxy herbicides on cell prolifertion of human lung fibroblasts
FGF2 and FGF10 are also expressed in adipose tissue and have each been implicated in adipogenesis.
Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis
FGF10 inhibits dominant follicle growth and estradiol secretion in vivo in cattle.
Steroidogenic enzymes mRNA expression profile and steroids production in bovine theca cells cultured in vitro and stimulated with angiotensin II/Perfil de expressao de RNAm de enzimas esteroidogenicas e producao de esteroides a partir de celulas da teca bovina cultivadas in vitro e estimuladas por Angiotensina II
The FGF10 is firstly expressed in the formative period of mammary line and regulates FGFR2b to affect Wnt10 response to the development of the mammary line.
Association of novel polymorphisms in lymphoid enhancer binding factor 1 (LEF-1) gene with number of teats in different breeds of pig
Stijn De Langhe, Ph.D., and his colleagues reported that destruction of lung tissue in mice induces smooth muscle cells surrounding the airways to secrete a protein known as fibroblast growth factor 10 (FGF10), which induces surviving epithelial cells in the airways to revert to a stem-cell state, proliferate, repair and repopulate the lining of die lungs.
Stem cells. signaling pathways identified in lung repair

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