FGF1


Also found in: Acronyms.

FGF1

A gene on chromosome 5q31 that encodes fibroblast growth factor 1 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF1 interacts with FGF receptors FGFR1, -2, -3 and -4.
References in periodicals archive ?
The candidates for such mitogenic mediators are the members of FGF family, such as FGF1, FGF2, FGF9 and FGF18 (6).
The Window of implantation is closed by Estrogen via insulin-like growth factor 1 pathway
Other studies have found that FGF1 may be exerting its insulin-sensitizing activity through the FGF1 receptor (FGFR1) in adipose tissue, although it can bind and activate all alternatively spliced forms of the four tyrosine kinase FGF receptors (FGFR1-FGFR4).
Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets
Several studies confirmed that expression of FGF1 and FGF2 in the injured cord is upregulated at the mRNA and protein level: FGF2, but not FGF1 mRNA, is upregulated after an incomplete thoracic contusion in spinal cord tissue including the lesion site [78].
The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury
Ocorre conflito de motorista com motorista, de agente da dengue com agente da dengue, de ACS com ACS [...], de ACS chegar a se pegar no tapa por questoes politicas" (FGF1).
Managerial Work in Basic Health Units of small municipalities in Parana, Brazil/Trabalho gerencial em Unidades Basicas de Saude de municipios de pequeno porte no Parana, Brasil/Gestion del trabajo en Unidades Basicas de Salud de pequenas ciudades en Parana, Brasil
Existing drugs can leave patients with dangerously low blood sugar and higher risks of heart problems but even at high doses, FGF1 did not cause those effects.
Diabetes jab gives hope
But even at high doses, researchers found that FGF1 does not trigger these side effects.
THE TWO-DAY DIABETES JAB; New drug to help millions; Tests find no side effects
US lead researcher Professor Ronald Evans, director of the Gene Expression Laboratory at the Salk Institute in La Jolla, California, said: "Controlling glucose is a dominant problem in our society and FGF1 offers a new method to control glucose in a powerful and unexpected way."
Protein hope in diabetes battle
TEHRAN (FNA)- In mice with diet-induced diabetes - the equivalent of type 2 diabetes in humans - a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days.
One Injection Stops Diabetes in Its Tracks
London, July 17 ( ANI ): A new animal study has revealed that a single injection of the protein FGF1 would be sufficient to balance the blood sugar levels to a healthy range for more than two days.
Soon, single jab will be enough to regulate diabetes
Mascarelli, "Paracrine effects of phosphorylated and excreted FGF1 by retinal pigmented epithelial cells," Growth Factors, vol.
Sanguis draconis, a dragon's blood resin, attenuates high glucose-induced oxidative stress and endothelial dysfunction in human umbilical vein endothelial cells
Direct binding of integrin [alpha]v[beta]3 plays a role in FGF1 signaling.
Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells
In mammalian systems,there are 22 FGFs, numbered FGF1 to FGF23, as FGF 15/19 represents a single FGF initially discovered in different species (mouse FGF15 and human FGF19; Ornitz and Itoh, 2001; Robinson, 2006).
FGF signaling is required for lens regeneration in Xenopus laevis
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