FGF1


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FGF1

A gene on chromosome 5q31 that encodes fibroblast growth factor 1 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF1 interacts with FGF receptors FGFR1, -2, -3 and -4.
References in periodicals archive ?
The candidates for such mitogenic mediators are the members of FGF family, such as FGF1, FGF2, FGF9 and FGF18 (6).
Other studies have found that FGF1 may be exerting its insulin-sensitizing activity through the FGF1 receptor (FGFR1) in adipose tissue, although it can bind and activate all alternatively spliced forms of the four tyrosine kinase FGF receptors (FGFR1-FGFR4).
Several studies confirmed that expression of FGF1 and FGF2 in the injured cord is upregulated at the mRNA and protein level: FGF2, but not FGF1 mRNA, is upregulated after an incomplete thoracic contusion in spinal cord tissue including the lesion site [78].
Existing drugs can leave patients with dangerously low blood sugar and higher risks of heart problems but even at high doses, FGF1 did not cause those effects.
But even at high doses, researchers found that FGF1 does not trigger these side effects.
US lead researcher Professor Ronald Evans, director of the Gene Expression Laboratory at the Salk Institute in La Jolla, California, said: "Controlling glucose is a dominant problem in our society and FGF1 offers a new method to control glucose in a powerful and unexpected way."
TEHRAN (FNA)- In mice with diet-induced diabetes - the equivalent of type 2 diabetes in humans - a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days.
London, July 17 ( ANI ): A new animal study has revealed that a single injection of the protein FGF1 would be sufficient to balance the blood sugar levels to a healthy range for more than two days.
Mascarelli, "Paracrine effects of phosphorylated and excreted FGF1 by retinal pigmented epithelial cells," Growth Factors, vol.
In mammalian systems,there are 22 FGFs, numbered FGF1 to FGF23, as FGF 15/19 represents a single FGF initially discovered in different species (mouse FGF15 and human FGF19; Ornitz and Itoh, 2001; Robinson, 2006).