FGF9

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FGF9

A gene on chromosome 13q11-q12 that encodes fibroblast growth factor 9 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF9 is produced mainly by neurons and may be important for glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumours. FGF9 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF9 cause multiple synostoses syndrome type 3.
References in periodicals archive ?
Some reports suggested that FGF-9 and FGF-18 inhibited extracellular production or had no significant effects at the early stage of chondrogenesis, but played an anabolic effect when added at the late stage [17, 27].
The concentrations of the first group, which included MCP-1, MCP-3, FGF-9, MIP-1[beta], and TIMP-1, reached nanogram levels.
Thirteen mediators exhibited ratios higher than 0.33 and had no significant differences between exudate and plasma concentrations (P > 0.05); these included MCP-1, MCP-3, FGF-9, IL-6, MIP-2, IFN-[gamma], MCP-5, IP-10, IL-1[alpha], IL-17A, OSM, SCF, and VEGF-A.