FGF8

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FGF8

A gene on chromosome 10q24 that encodes fibroblast growth factor 8 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF8 is expressed in adults only in the testes and ovaries; it is required for normal brain, eye, ear and limb development during embryogenesis, and for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. FGF8 interacts with FGF receptors FGFR1, -2, -3 and -4.

Molecular pathology
Defects in FGF8 cause Kallmann syndrome type 6.
References in periodicals archive ?
Slack, "FGF-8 is associated with anteroposterior patterning and limb regeneration in Xenopus," Developmental Biology, vol.
Izpisua-Belmonte, "Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb," Development, vol.
Sharpe, "Fgf-8 determines rostral-caudal polarity in the first branchial arch," Development, vol.
Migracion: En cuanto a la proliferacion de las CGP durante la fase migratoria, estas son estimuladas de forma paracrina por las celulas vecinas mediante FGF-4, FGF-8 y FGF-17.
Postmigracion: Al llegar las CGP al esbozo gonadico, estas comienzan a secretar FGF-4 y FGF-8 para estimular su proliferacion de manera autocrina (Kawase et al., 2004).
Fgf-8 has been proposed to work antagonistically with Bmp-4 to specify the sites of tooth initiation.It is also shown that mesenchymal Bmp-2 & epithelial Bmp-4 antagonise the induction of mesenchymal Pax -9 by Fgf-8.(Figure 1)
Both Bmp-4 & Fgf-8 exhibit close interactions with each other(Fig 2).Another posssible regulator of FGF-8 is Pitx-2 whose epithelial expression prefigures the location of teeth.Pitx-2 has been shown to be required for the progression beyond epithelial thickening or bud stage.Pitx-2 seems to regulate Fgf-8 in a positive feedback mechanism while Bmp-4 in a negative feedback mechanism.