FGFR2

(redirected from FGF receptor)

FGFR2

A gene on chromosome 10q25.3-q26 that encodes fibroblast growth factor receptor-3, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR3 mutations are associated with Apert syndrome, Beare-Stevenson cutis gyrata syndrome, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome and syndromic craniosynostosis.
References in periodicals archive ?
The levels of [sz]-Klotho and FGF receptor 1 (FGFR1) protein were measured by enzyme-linked immunosorbent assay (ELISA).
Taeschler, "Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor," Biochimica et Biophysica Acta (BBA)--Gene Structure and Expression, vol.
In the kidney, FGF-23 binds to FGF receptor in the proximal tubule in the presence of coreceptor klotho resulting an inhibition of proximal tubular phosphate reabsorption and a suppression of 1,25-dihydroxy vitamin D synthesis [31].
Filion et al., "Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis," The Journal of Biological Chemistry, vol.
A possible outcome improvement strategy for this and other studies might be the combined overexpression of the FGF receptor and ligand as opposed to our study which only used overexpression of the FGFR1.
Motomura-Matsuzaka et al., "[beta]Klotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c," Molecular Endocrinology, vol.
[4] Nonstandard abbreviations: FGF, fibroblast growth factor; FGFR, FGF receptor; FHF, fibroblast homologous factor; SLC2A1, solute carrier family 2 (facilitated glucose transporter), member 1; GLUT1, glucose transporter 1.
Moreover, FGF23 was shown to induce cardiomyocyte hypertrophy via PLC-[gamma] signaling rather than ERK signaling, which was dependent on FGF receptor activation but independent of Klotho.
Altogether it is tempting to speculate that CNPY family members act as cochaperones of GRP94 with CNPY1 assisting FGF receptor folding, CNPY2 LDL receptor maturation, and that pERp1/MZB1 may drive IgM polymerization by virtue of its assistance to or modulation of GRP94 function.
Altered FGF receptor expression has been found in pituitary adenomas [48], and FGFR4 undergoes alternative transcription initiation in pituitary adenomas, giving rise to an oncogenic protein in pituitary adenomas of various subtypes.
Phinney, "Fibroblast growth factor 2 (FGF-2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering fgf receptor expression levels," Stem Cells, vol.