FGFR2

(redirected from FGF receptor)

FGFR2

A gene on chromosome 10q25.3-q26 that encodes fibroblast growth factor receptor-3, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR3 mutations are associated with Apert syndrome, Beare-Stevenson cutis gyrata syndrome, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome and syndromic craniosynostosis.

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The levels of [sz]-Klotho and FGF receptor 1 (FGFR1) protein were measured by enzyme-linked immunosorbent assay (ELISA).

Protection Effect of Exogenous Fibroblast Growth Factor 21 on the Kidney Injury in Vascular Calcification Rats

Taeschler, "Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor," Biochimica et Biophysica Acta (BBA)--Gene Structure and Expression, vol.

FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling

In the kidney, FGF-23 binds to FGF receptor in the proximal tubule in the presence of coreceptor klotho resulting an inhibition of proximal tubular phosphate reabsorption and a suppression of 1,25-dihydroxy vitamin D synthesis [31].

Phosphate and Cardiovascular Disease beyond Chronic Kidney Disease and Vascular Calcification

Filion et al., "Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis," The Journal of Biological Chemistry, vol.

Synergistic Effects of FGF-18 and TGF-[beta]3 on the Chondrogenesis of Human Adipose-Derived Mesenchymal Stem Cells in the Pellet Culture

A possible outcome improvement strategy for this and other studies might be the combined overexpression of the FGF receptor and ligand as opposed to our study which only used overexpression of the FGFR1.

The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury

Motomura-Matsuzaka et al., "[beta]Klotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c," Molecular Endocrinology, vol.

Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit

Structural and functional diversity in the FGF receptor multigene family.

Role of postnatal expression of Fgfr1 and Fgfr2 in testicular germ cells on spermatogenesis and fertility in mice

[4] Nonstandard abbreviations: FGF, fibroblast growth factor; FGFR, FGF receptor; FHF, fibroblast homologous factor; SLC2A1, solute carrier family 2 (facilitated glucose transporter), member 1; GLUT1, glucose transporter 1.

Severe hypophosphatemia in a 79-year-old man

Moreover, FGF23 was shown to induce cardiomyocyte hypertrophy via PLC-[gamma] signaling rather than ERK signaling, which was dependent on FGF receptor activation but independent of Klotho.

Cardiovascular risk factors and chronic kidney disease--FGF23: a key molecule in the cardiovascular disease

Altogether it is tempting to speculate that CNPY family members act as cochaperones of GRP94 with CNPY1 assisting FGF receptor folding, CNPY2 LDL receptor maturation, and that pERp1/MZB1 may drive IgM polymerization by virtue of its assistance to or modulation of GRP94 function.

Missing links in antibody assembly control

Altered FGF receptor expression has been found in pituitary adenomas [48], and FGFR4 undergoes alternative transcription initiation in pituitary adenomas, giving rise to an oncogenic protein in pituitary adenomas of various subtypes.

Angiogenesis in pituitary adenomas: human studies and new mutant mouse models

Phinney, "Fibroblast growth factor 2 (FGF-2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering fgf receptor expression levels," Stem Cells, vol.

Impact of ellagic acid in bone formation after tooth extraction: an experimental study on diabetic rats