FFAR3

A gene on chromosome 19q13.1 that encodes a receptor for short-chain free fatty acids, the activity of which is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilisation, the activation of ERK 1/2 and inhibition of intracellular cAMP
accumulation.

References in periodicals archive ?

One of the overactive genes that helps trigger the inflammation response -- a gene called FFAR3 -- also encodes a receptor for a dietary supplement called butyrate.

Which Cells Drive a Painful Food Allergy?

Targeting Ffar2 (GPR43) and Ffar3 (GPR441) and down-regulating NF-?B, this patent covers the company's first major drug, SFA001, and provides a way of treating patients afflicted with hepatitis B.

SFA Therapeutics Wins US Patent for Use of Short Chain Fatty Acids in Cancer Prevention. New Treatment for Hepatitis B

3) El butirato interactua con los receptores FFAR3 (Free Fatty Acid Receptor 3), estimulando la produccion de peptidos anorexigenicos como PYY y GLP-1 (55).

Efecto de inulina en la saciedad en humanos/Inulin Effect in Human Satiety

Gille et al., "GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes," Endocrinology, vol.

The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus

Merold et al., "Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity," Gene, vol.

Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes

Our microarray data revealed that PMNs express a number of cell surface receptors for the recognition of iRBCs, including protein G receptors (P2RY4, GPR88, MRGPRG, FFAR3, HCAR1, and MRGPRF), adhesion receptors (VIT, CD69), sialic acid (SIGLEC12), Fc receptors (FCGR1a, FCRL1), FLNA, and IL-15RA.

Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes

found that SCFA butyrate suppressed colonic stem cell proliferation [112], perhaps through receptors encoded by Ffar3, Ffar2, and Niacr1 [113].

Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche

This Fellowship project has two main objectives: Investigating the role of islet short chain fatty acid receptors (FFAR2 and FFAR3) in regulating beta-cell function and identifying novel islet GPCRs that regulate insulin secretion and/or beta-cell mass.

BRIDIT: Beta-cell Receptors in Diabetes Therapy

(2014) Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity.

Metagenomics health claim: are you rich enough in your gut micro biota?

Receptors for SCFAs are two Gprotein coupled receptors (GPCRs): FFAR2 (free fatty acid receptor2, previously known as GPR43) and FFAR3 (or GPR41) [37-40].

In particular the promoter region of FFAR3 showed a significantly higher methylation in the lean control group compared to type 2 diabetics and to obese subjects.

Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes

GPR41 (i.e., FFAR3) and GPR43 (i.e., FFAR2) are both highly expressed on immune cells such as polymorphonuclear cells and macrophages [ 22].