FEN1

FEN1

A gene on chromosome 11q12 that encodes a protein belonging to the XPG/RAD2 endonuclease family, which removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging-strand DNA synthesis. Direct physical interaction between FEN1 and AP endonuclease 1 during long-patch base excision repair provides co-ordinated loading of the proteins onto the substrate, passing the substrate from one enzyme to another.
Mentioned in ?
References in periodicals archive ?
5' nucleases, the superfamily to which FEN1 belongs,represent structure-specific nucleases essential for DNA replication, repair, and recombination.
The KAUST scientists were able to build a timeline of up to seven intermediary steps before FEN1 commits to catalysis.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.
The team has also used the technique to analyze functions of the p53 gene (a tumor suppressor that is the most commonly mutated gene in human cancers); to study the human FEN1 gene (important in DNA replication and repair); and to evaluate the stability of DNA sequences from the human genome.