FEIBA


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FEIBA

Factor VIII inhibitor–see there, or factor VIII bypassing activity. See Prothrombin complex concentrate.
References in periodicals archive ?
Aherens et al., "The role of FEIBA in reversing novel oral anticoagulants in intracerebral hemorrhage," Neurocritical Care, vol.
In rats receiving rivaroxaban, high-dose 4F-PCC was shown to produce the most profound decrease in mesenteric bleeding time (versus FEIBA and activated factor VII).
The approval is based on data from a Phase III trial known as FEIBA PROOF, under which treatment with a FEIBA prophylactic regimen indicated a 72% reduction in median annual bleed rate against treatment with an on-demand regimen.
(11,12) Treatment strategies to control active bleeding include the use of desmopressin (DDAVP), Factor VIII concentrate, activated prothrombin complex or APC (FEIBA - Anti-inhibitor coagulant factor), and Recombinant VIIa (NovoSeven).
Specialised 'bypass' therapies such as FEIBA or Novoseven have been developed, and require highly specialised input as they are extremely expensive, and may not be effective if given incorrectly.
Porcine factor VIII and activated factor VII are new products for this type of patient, and prothrombin complex concentrates (Autoplex[R] and Feiba) are used (79).
No se debe usar con FEIBA u otro concentrado de complejo protrombinico, porque potencian los efectos trombogenicos (8).
have reviewed all reported patients with hemophilia A and hemophilia B in the literature and found that the administration of factor VIII inhibitor bypassing activity (FEIBA) or recombinant activated FVII (rFVIIa) in patients with inhibitors and surgery was the most frequent risk factor for thromboembolism development in hemophilia A and B patients, respectively, in addition to variable prothrombotic conditions and administration of prothrombin complex concentrate (PCC) [9].
Comments: Hematology revenues were $855 million, excluding the impact of foreign exchange, grew 6% in the quarter driven by ADVATE, a treatment for hemophilia A, and double-digit growth of FEIBA, an inhibitor treatment.