Pulmonary medicine A clinical test that measures the forced expiratory flow from 25% to 75% of vital capacity, which was once thought to be one of the most sensitive, simplest, and least expensive methods for evaluating small airways disease
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Regression coefficients are provided for FVC, FEV1, FEV1/FVC, FEF25%-75%, and PEF (peak expiratory flow).
One exception to this finding is the predicted values for FEF25%-75% which tend to be slightly lower, at least in comparison to some older studies.
(p>0.05: not significant) TABLE 3: Comparison of PFT between carpet weavers and controls Parameters Carpet weavers Controls P value FVC 2.01 [+ or -] 0.24 3.25 [+ or -] 0.42 P<0.001 * FEV1 1.44 [+ or -] 0.25 3.82 [+ or -] 0.45 P<0.001 * FEV1/FVC 70.2 [+ or -] 12.6 85.8 [+ or -] 5.9 P<0.001 * FEF25%-75% 3.65 [+ or -] 1.45 4.81 [+ or -] 1.03 P<0.001 * PEFR 4.58 [+ or -] 2.02 6.24 [+ or -] 1.62 P<0.001 * All values are expressed as Mean [+ or -] SD.
In each study, the groups given rolling assessments and education had significant improvements in forced expiratory flow (FEF25%-75%) over baseline measures.
However, there were no statistically significant differences between denufosol and placebo for three key secondary endpoints including rate of change in percent predicted FEV1 over 48 weeks, change from baseline in FEF25%-75% (Forced Expiratory Flow) at the week 48 endpoint and time to first pulmonary exacerbation.
In children, the forced expiratory flow over the middle half of forced vital capacity, or FEF25%-75%, is a more sensitive indicator of airflow obstruction than is [FEV.sub.1], he said.