MLH1

(redirected from FCC2)

MLH1

A human homologue of the Escherichia coli DNA mismatch repair gene on 3p21.3, which encodes an enzyme that scans newly replicated DNA for errors and repairs mismatched base pairs.

Molecular pathology
A germline mutation of MLH1 occurs in ± 1% of patients with hereditary nonpolyposis colon cancer; defects in MLH1 also cause mismatch repair cancer syndrome, Muir-Torre syndrome and susceptibility to endometrial cancer.
References in periodicals archive ?
The FCP1 Connector Cleaning Kit, for example, includes various configurations of FCC2 connector cleaning fluid, CCT connector cleaning tips, FiberWipes, Cletop cartridge cleaner, Cletop (ACT) cleaning sticks, and Noyes VS 300 Inspection Scope.
Vehicle emission factors were developed for winter (55[degrees]F/50% relative humidity) and summer (75[degrees]F/50% relative humidity) conditions using average speeds of 65 mph on freeways and high-ways [FCC (functional class code) 1 and FCC2 class roads], 50 mph on major arterials (FCC3 class roads), and 30 mph on minor arterials and collectors (FCC4 roads).
reputed as having captured the FCC2 (260)--asked the FCC to rule that
KEY: FCC2 (Frizzel County Championship, Division Two); TSL2 (totesport League, Division Two); C&G (Cheltenham & Gloucester Trophy); Twenty20 (Twenty20 Cup); TOM (tour match); UNI/UCCE (University Cricketing Centre of Excellence).
13 Leics, Grace Road (FCC2); 17 Leics, Grace Road (TSL2); 20 Worcs, Riverside (FCC2); 24 Surrey, Riverside (TSL2).
Wed 13: Leicestershire (away) FCC2; Sun 17: Leicestershire (away) TSL2; Wed 20: Worcestershire (home) FCC2; Sun 24: Surrey (home) TSL2.
Sun 1: Scotland (away) TSL2; Mon 2: Sussex (home) TSL2; Tue 3: Derbyshire (home) CGT1; Fri 6: Somerset (home) FCC2; Wed 11: Lancashire (away) FCC2; Sun 15: Yorkshire (home) TSL2; Tue 17: Wiltshire/Kent (home) CGT2; Fri 20: Yorkshire (home) FCC2; Sun 29: Kent (away) TSL2; Mon 30: Surrey (away) TSL2.
Probes FCC1 and FCC2 detected loci on all three homeologs, and FCC3 detected loci on chromosomes 5B and 5D.
The clones derived from Stage II chemostat lines were designated FBC1, FBC2, FBCr1, FBCr2, FCC1, FCC2, FCCr1, FCCr2, SBC1, SBC2, SBCr1, and SCCr1.
July 9 - Northamptonshire, Riverside (FCC2); July 13 - Northamptonshire, Riverside (NCL2).