KDM2B

(redirected from FBXL10)

KDM2B

A gene on chromosome 12q24.31 that encodes lysine-specific demethylase 2B, which demethylates histone H3. KDM2B preferentially binds the transcribed region of ribosomal RNA, represses ribosomal RNA gene transcription and inhibits cell growth and proliferation. It may also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F)-box protein-type E3 ubiquitin ligase complex.
References in periodicals archive ?
H3K4 is demethylated by the KDM1 family (LSD1 and AOF1), the KDM2 family (FBXL10), and the KDM5 family (JARID1A, JARID1B, JARID1C, and JARID1D) as well as JARID2 and NO66.
H3K36 is demethylated by the KDM2 family (FBXL10 and FBXL11), the KDM4 family (JMJD2A, JMJD2B, and JMJD2C), and NO66.
If Fbxl10 is not present in embryonic stem cells, the cells cannot differentiate properly and this can lead to developmental defects," said Prof.
"Our results show that Fbxl10 is essential for recruiting PRC1 to genes that are to be silenced in embryonic stem cells.
"Given the emerging relationship between cancer and stem cells, our findings may implicate that an aberrant activity of Fbxl10 can disturb PRC function and promote a lack of differentiation in our cells.