(204,205) FOXL2 is also reported in female adnexal tumor of wolffian origin (FATWO) and 50% of Sertoli-Leydig cell tumors.
Similarly, immunohistochemistry helps in differentiating FATWO, a rare tumor arising in the broad ligament, mesosalpinx, and ovary, (58) from the low-grade endometrioid adenocarcinoma variant of the fallopian tube.
Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin.
INTRODUCTION: Female Adnexal Tumor of probable Wolffian Origin (FATWO) or Wolffian adnexal tumor (WAT) according to WHO-classification is a rare neoplasm originating from Wolffian remnants.
DISCUSSION: FATWO are rare neoplasms believed to originate from mesonephric (Wolffian) remnants because of its location in areas where these remnants are abundant, presence of a thick peritubular basal lamina and absence of cilia, secretary granules and glycogen.
CONCLUSION: Rarity and variable location of FATWO make the diagnosis difficult and in view of recurrence, long term follow up is necessary.
The pathology revealed a characteristic pattern for FATWO tumors, including solid neoplastic epithelial cells in "closely packed branching tubules," said Dr.
Steed and her associates revealed 72 reported FATWO cases, including 8 that recurred.
The median age of a patient diagnosed with FATWO was 50, with a range from 15 to 83 years.