PALB2

(redirected from FANCN)

PALB2

A gene on chromosome 16p12.2 that encodes a protein thought to function in tumour suppression. PALB2 binds to and co-localises with breast cancer 2 early-onset protein (BRCA2) in nuclear foci, and allows its stable intranuclear accumulation.
References in periodicals archive ?
[34] Solid-tumour risk for carriers of other rare FA genes, including FANCN (PALB2) and FANCO (RAD51C), is established in cohorts of patients with breast and/or ovarian cancer, with increased risks for breast cancer (33-58% in PALB2)[35] and ovarian cancer (<9% in RAD51C).