BRIP1

(redirected from FANCJ)

BRIP1

A gene on chromosome 17q22.2 that belongs to the the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex plays a role in double-strand break repair by BRCA1. BRIP1 may be a target of germline cancer-inducing mutations.
References in periodicals archive ?
Fanconi anemisi ile iliskili genlerden BRIP1 (FANCJ) (11, 21, 22) geninin onemli DNA tamir yolaklarindan biri olan FA-yolaginda yer aldigi ve monoubikuitine-FANCD2'nin BRCA1 ile etkilesimi icin gerekli olan bir helikaz geni oldugu gosterilmistir (23, 24).
Repair of G-Quadruplex DNA Facilitated by the FANCJ Helicase and the REV1 Polymerase.
White, "The DNA repair helicases XPD and FancJ have essential iron-sulfur domains," Molecular Cell, vol.