FANCD2

FANCD2

A gene on chromosome 3p26 that encodes a protein of the Fanconi anaemia complementation group (here, complementation group D2), which co-locates with other proteins—e.g., BRCA1 and BRCA2—and is involved in homology-directed DNA repair.
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Genes Tested AtP ALK APC ATM BAP1 BRCA2 BRIP1 BUB1B CDC73 CDH1 CEP57 CHEK2 CYLD DDB2 DICER1 ERCC3 ERCC4 ERCC5 EXT1 EXT2 FANCD2 FANCE FANCF FANCG FANCI GATA2 GPC3 HNF1A HOXB13 HRAS MLH1 MHS2 MSH6 MUTYH NBN PHOX2B PMS1 PMS2 PPM1D PRF1 RAD51D RBI RECQL4 RET RHBDF2 SDHC SDHD SLX4 SMAD4 SMARCA4 TP53 TSC1 TSC2 VHL WT1 BARD1 BLM BMPR1A BRCA1 CDK4 CDKN1C CDKN2A CEBPA DI53L2 EGFR EPCAM ERCC2 EZH2 FANCA FANCB FANCC FANCL FANCM FH FLCN KIT MAX MEN1 MET NF1 NF2 NSD1 PALB2 PRKAR1A PTCH1 PTEN RAD51C RUN XI SBDS SDHAF2 SDHB SMARCB1 STK11 5UFU TMEM127 WRN XPA XPC This chart shows all 98 cancer susceptible genes included in this new test.
RING, RING (really interesting new gene) domain; PALB2, partner and localizer of BRCA2; BRCT, BRCA1 c-terminus domain; NPM1, nucleophosmin 1; POLH, DNA polymerase eta; FANCD2, Fanconi anemia complementation group D2; SHFM1/DSS, 26S proteasome complex subunit protein DSS (deleted in split hand/split foot), encoded by the gene SHFM1; BRC repeats, breast cancer repeats; NES, nuclear export signal.
We will define, on an atomic level, the site-specific monoubiquitination and deubiquitination cycle of FANCD2 in its entirety.
ATM-dependent phosphorylation of BRCA1, NBS1 and two additional players in the NBS1 branch of the pathway the SMC1, a chromosomal structural maintenance protein and FANCD2, a Fanconi anemia complementation group D2 protein, both are needed for an intact intra-S phase checkpoint (Shiloh et al.
Scientists had shown previously that DNA repair was much less efficient when FANCI and FANCD2 lack the single ubiquitin.
Researchers have shown exposure to cigarette smoke slows production of a protein called FANCD2 in lung cells.