BRCA2

(redirected from FANCD1)

BRCA2

symbol for a breast cancer gene with activity similar to that of BRCA1.

BRCA2

A gene on chromosome 13q12.3 that encodes a protein which, like BRCA1, is involved in maintenance of genome stability, especially the homologous recombination pathway for double-stranded DNA repair; like BRCA1, it carries a marked increase in the lifetime risk of breast and ovarian cancer.

BRCA2

Molecular oncology A tumor suppressor gene linked to breast and ovarian CA See Tumor suppressor gene.
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20,24] Although the VACTERL/H phenotype appears to be more often associated with mutations in FANCD1 (33%), E (40%) and F (30%), more recent work by Alter and Giri [20] suggests that the co-occurrence of this phenotype with FA is under-recognised.
Fanconi anaemia in South African patients with Afrikaner ancestry

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