FANCD1 | definition of FANCD1 by Medical dictionary
BRCA2 (redirected from FANCD1)
symbol for a breast cancer gene with activity similar to that of BRCA1.
BRCA2 A gene on chromosome 13q12.3 that encodes a protein which, like BRCA1, is involved in maintenance of genome stability, especially the homologous recombination pathway for double-stranded DNA repair; like BRCA1, it carries a marked increase in the lifetime risk of breast and ovarian cancer.
BRCA2 Molecular oncology A tumor suppressor gene linked to breast and ovarian CA See Tumor suppressor gene.
References in periodicals archive
20,24] Although the VACTERL/H phenotype appears to be more often associated with mutations in FANCD1
(33%), E (40%) and F (30%), more recent work by Alter and Giri  suggests that the co-occurrence of this phenotype with FA is under-recognised.