FANCC | definition of FANCC by Medical dictionary
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FANCC A gene on chromosome 9q22.3 that encodes a protein of the Fanconi anaemia complementation group (here, complementation group C), the members of which are related not by sequence similarity, but rather by their assembly into a common nuclear protein complex.
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References in periodicals archive
Patients with mutations in FANCA show a mild endocrine phenotype in which height is not severely affected and insulin resistance is mild, whereas mutations in FANCC
, which are related to shorter stature, have the least insulin resistance .
The genetics of FANCC
and FANCG in familial pancreatic cancer.
The genes of the Fanconi anemia pathway involved in pancreatic tumorigenesis include the FANCC
and FANCG genes and most notably the BRCA2 gene.