GOT2

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GOT2

A gene on chromosome 16q21 that encodes the inner-membrane mitochondrial form of glutamic-oxaloacetic transaminase, a pyridoxal phosphate-dependent enzyme that also exists as a cytoplasmic form (GOT1). GOT1 and -2 both play key roles in amino acid metabolism and the urea and tricarboxylic acid cycles, as well as in the exchange of metabolites between mitochondria and cytosol. GOT2 facilitates cellular uptake of long-chain free fatty acids.
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increased FAT/CD36 and FABPpm content in whole muscle, FABPpm in the
Plasma membrane-associated fatty acid binding proteins (FABPpm) and fatty acid translocase/CD36 (FAT/CD36) are among several key proteins that have been identified as fatty acid transporter proteins in human and animal muscles [221].
Cardiac cells can take up circulating FA (as albumin associated with or coupled in lipoproteins) by simple diffusion across the plasma membrane or by FA transporters (i.e., FAT/CD36, FABPpm, and FATP1, -4, and -6 [55] (Figure 2(b)).