FABP7

FABP7

A gene on chromosome 6q22-q23 that encodes a brain fatty acid-binding protein possibly involved in the transport of an as-yet unknown hydrophobic ligand with potential morphogenic activity during CNS development. FABP7 is required for establishing the radial glial fibre system in the developing brain, which is necessary for the migration of immature neurons to establish cortical layers.
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These genes encoded proteins primarily involved in integrin signalling pathways (ACTA2, PIK3C2G, COL4A6, CAV1, LAMA1, FN1, and ITGA8), regulation of hormone levels (NR5A1, TIPARP, ACE, CRYM, CGA, ALDH1A1, TBX3, POMC, GHRH, and ALDH6), camera-type eye development (TGFBR2, BMP4, FABP7, STRA6, SIX6, and WNT6), blood vessel development (Figure S1, goo.gl/tC9GTZ), and regulation of cellular response to growth factor stimulus (see Figure 2).
Among Fabps, Fabp3 (H-Fabp), Fabp5 (E-Fabp, KFabp, or S-Fabp) and Fabp7 (BLBP or B-Fabp) are the members expressed in the brain.
Fabp5 and Fabp7 are strongly expressed in the embryonic brain, but no detectable abnormalities are reported in the gross anatomy of the brain of Fabp5 and Fabp7 KO mice [120,130].
Osumi, "The effects of fabp7 and fabp5 on postnatal hippocampal neurogenesis in the mouse," Stem Cells, vol.
Owada et al., "Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype," PLoS Biology, vol.
Although 36 differentially expressed genes were identified in this analysis, only 3 genes (FABP7, PCNA, and L1CAM) were validated by using quantitative polymerase chain reaction (PCR).
205029_s_at Fatty acid binding protein 7, brain; 6q22-q23 FABP7 HGNC; 6631FA metabolism; 6810 transport; 7399 neurogenesis; 8285 negative regulation of cell proliferation; 5215 transporter activity; 5478 Intracellular transporter activity; 8289 lipid binding.
OVEREXPRESSION of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance.
Gingele et al., "Brain lipid binding-protein (FABP7) as modulator of astrocyte function," Physiological Research, vol.